Basal metabolic rate of aged mice is affected by random genetic drift but not by selective breeding for high early-age locomotor activity or chronic wheel access

Physiological and Biochemical Zoology : PBZ
Stephanie L KaneP A Carter

Abstract

The study of correlated evolution can lead to new insights about the inheritance patterns of complex traits. In order to better understand the evolution of metabolic rate, we tested whether voluntary activity levels and basal metabolic rate are genetically correlated in 90-wk-old mice (Mus domesticus) from replicated lines of the sixteenth generation of an artificial selection experiment for high early-age wheel-running activity. We measured basal rates of oxygen consumption and carbon dioxide production and also computed the respiratory exchange ratio. Half of the individuals from both selected and control lines had been allowed free access to running wheels since 4 wk of age, while the other half were in standard cages. This design allowed testing of hypotheses about (1) genetic correlations between voluntary activity and metabolic rate and (2) lifetime training effects on metabolic traits. Selection group did not have a significant effect on metabolic traits; therefore, this study does not support some of the implicit assumptions of the aerobic capacity model for the evolution of vertebrate energetics. Activity group also did not affect metabolic rate, indicating that lifetime training does not alter basal metabolism in thes...Continue Reading

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Citations

Aug 1, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Marek Konarzewski, Aneta Książek
Aug 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M VaanholtG van Dijk
Oct 27, 2012·Physiological and Biochemical Zoology : PBZ·Vincent Careau, Theodore Garland
Apr 11, 2015·Physiological and Biochemical Zoology : PBZ·Julita SadowskaMarek Konarzewski
Feb 4, 2009·Evolution; International Journal of Organic Evolution·Edyta T SadowskaPaweł Koteja
Apr 17, 2015·Proceedings. Biological Sciences·Edyta T SadowskaPaweł Koteja
Apr 13, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·David L SwansonFrançois Vézina
Oct 17, 2014·Proceedings. Biological Sciences·Hanne LøvlieGöran Arnqvist
Sep 25, 2019·The Journal of Experimental Biology·Małgorzata M LipowskaPaweł Koteja
Apr 5, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael D RobertsFrank W Booth
Aug 18, 2009·The Journal of Experimental Biology·Andrzej K Gebczyński, Marek Konarzewski

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