Basal metabolism does not account for high O2 consumption in stunned myocardium

The American Journal of Physiology
Jochen D SchipkeG Arnold

Abstract

Myocardial O2 consumption (MVo2) in stunned myocardium is relatively high compared with the reduced ventricular function. The mechanism of this "oxygen paradox" could occur at different levels: basal metabolism, excitation-contraction coupling, and energy production. In one previously reported series on 12 isolated, blood-perfused rabbit hearts, left ventricular systolic and diastolic function in stunned myocardium were significantly decreased compared with control, whereas total MVo2 was not. The MVo2 for the unloaded contraction was overproportionately high for the decreased function in stunned myocardium, and contractile efficiency was clearly deteriorated. To assess whether the basal metabolism specifically is elevated in stunned myocardium, a second series (n = 14) with a similar protocol was performed in this study. Basal MVo2 after KCl arrest (0.5 +/- 0.3 ml.min-1.100 g-1) was significantly lower than that measured after KCl arrest (1.2 +/- 0.5 ml.min-1.100 g-1) in an additional series on nonischemic hearts (n = 8). Our conclusion is that basal MVo2 in stunned myocardium is not elevated. Thus this O2-consuming portion of total MVo2 is not responsible for the inefficiency in stunned myocardium. Instead, a "metabolic stunn...Continue Reading

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Citations

Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S LeeH Suga
Jul 14, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S B ReederD A Bluemke
Jun 21, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Warren H LeeMichael S Wolin
Jun 1, 2008·Proteomics. Clinical Applications·Melanie Y WhiteJennifer E Van Eyk

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