PMID: 8954753Dec 1, 1996Paper

Basal metabolism of intraperitoneally injected carrier-free 74As-labeled arsenate in rabbits

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J D KimpeR Vanholder

Abstract

The time-dependent occurrence of [74As]arsenate metabolites in Flemish Giant rabbits was investigated. As absorbed rapidly, reaching maximal concentrations in plasma and packed cells after 30 min and 2 hr, respectively. The [74As]arsenate in plasma and packed cells was reduced to [74As]arsenite, to 35 and 50% of the total 74As, respectively. The concentration of methylated As species in plasma and packed cells increased rapidly after 30 min. About 18% of total plasma 74As maximally bound to transferrin. Two-thirds of total 74As in packed cells bound to hemoglobin. Whereas little or no [74As]monomethylarsonic acid, one of the main As metabolites in humans, could be found in other animals, it is present in measurable amounts in the Flemish Giant. Furthermore, the plasma clearance rate of 74As species is lower than that in other rabbits and more similar to that of humans. The tissue 74As distribution varied widely with the highest concentrations in kidneys, liver, and lungs. 74As accumulated in bone whereas other tissues and blood showed rapid clearance rates. In muscle and heart an important part of arsenic was associated with components insoluble in phosphate-buffered isotonic saline. Binding of arsenic to soluble tissue protein...Continue Reading

Citations

May 18, 1999·Biological Trace Element Research·S M HealyH V Aposhian
Jun 12, 1999·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·J De KimpeR Vanholder
Jun 30, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M S GolubN Baumrind

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