Basal plasma glucagon levels of man

The Journal of Clinical Investigation
J E Sokal, E Z Ezdinli

Abstract

The isolated perfused rat liver can serve as a bioassay system for glucagon, capable of detecting 10 mmug of this agent. Seven 15-ml plasma specimens obtained from different healthy volunteers after an overnight fast were assayed in this system; glucagon could not be detected in any of them, indicating concentrations significantly below 0.67 mmug per ml in all subjects. The effects of administering small doses of glucagon to patients were consistent with these results; imposition of increments to plasma glucagon concentration below 1 mmug per ml induced distinct and sustained increases in blood glucose. Observations of the biologic effects of glucagon, together with data on the rate of its inactivation by the liver, suggest that the basal concentration of this hormone in peripheral plasma probably does not exceed 0.1 mmug per ml.

References

Dec 18, 1965·Lancet·E SamolsV Marks
Feb 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A M Lawrence
Sep 1, 1966·The American Journal of Medicine·J E Sokal
Jan 1, 1966·Endocrinology·E Z Ezdinli, J E Sokal
Jul 1, 1963·The Journal of Clinical Investigation·R H UNGERL L MADISON

❮ Previous
Next ❯

Citations

Jun 1, 1969·Diabetologia·P J Lefebvre, A S Luyckx
Jun 1, 1979·Diabetologia·P J Lefebvre, A S Luyckx
Dec 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Shima, P P Foà
Jul 16, 1970·The New England Journal of Medicine·P Felig
Dec 1, 1970·The Journal of Clinical Investigation·E B MarlissG F Cahill
Oct 1, 1971·The Journal of Clinical Investigation·J Iversen
Aug 1, 1968·The American Journal of Medicine·D H MintzA Fefer
Apr 1, 1968·Acta diabetologica latina·P Lefebvre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Australian Journal of Experimental Biology and Medical Science
J D Young, I S Jenkinson
Biochemical and Biophysical Research Communications
R WorobecE Deininger
The Journal of Clinical Investigation
R H UNGERL L MADISON
© 2021 Meta ULC. All rights reserved