Basal vitamin D levels and disease activity in multiple sclerosis patients treated with fingolimod

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
L Ferre'F Esposito

Abstract

Several studies have shown an association between 25-hydroxyvitamin D (25[OH]D) levels and multiple sclerosis (MS) susceptibility and/or level of disease activity in patients treated with first line drugs. To investigate whether baseline 25[OH]D values could influence disease activity also during treatment with the second-line drug fingolimod (FTY). We enrolled 176 MS patients who started FTY at the San Raffaele Hospital (OSR) MS center with available 25[OH]D measurement at the time of treatment start. We then prospectively followed them for 2 years with periodic clinical examinations and MRI scans. We found no linear correlation between baseline 25[OH]D levels and annualized relapse rate (ARR) or time to first relapse. However, we observed that patients with serum 25[OH]D ≥ 100 nmol/l showed a lower number of Gd+ and combined unique activity (CUA) lesions at baseline compared to patients with the lowest 25[OH]D levels (less than 50 nmol/l, p value < 0.05). Moreover, they showed fewer CUA lesions at 2-year follow-up also when accounting for baseline level of disease activity (p value < 0.05). In patients treated with FTY, those with the highest baseline 25(OH)D levels had a significantly lower number of active lesions at baseli...Continue Reading

References

Dec 21, 2006·JAMA : the Journal of the American Medical Association·Kassandra L MungerAlberto Ascherio
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jul 10, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Vittorio MartinelliGiancarlo Comi
Jan 22, 2014·JAMA Neurology·Alberto AscherioChristoph Pohl
Apr 26, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Erdem Tüzünİlhan Yaylım
Nov 17, 2015·Neurology. Neuroimmunology and Neuroinflammation·Dalia L RotsteinTanuja Chitnis

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Citations

Oct 15, 2018·Acta Neurologica Scandinavica·Trygve HolmøyMargitta T Kampman
Jul 25, 2020·Brain and Behavior·Katariina HänninenMerja Soilu-Hänninen
Jul 20, 2019·Autoimmunity Reviews·Giuseppe MurdacaSebastiano Gangemi

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