Abstract
Follicular mucinosis, papules, cysts and comedones have been previously described as expressions of follicular involvement by mycosis fungoides. We report a patient with mycosis fungoides who developed extensive alopecia. Multiple scalp biopsies showed perifollicular and intrafollicular infiltrate of lymphocytes but no evident follicular mucinosis. On transverse sections many of the follicles showed an absence of differentiation towards hair sheath, canal, sebaceous gland or hair formation, but instead formed undifferentiated basaloid structures. These basaloid structures showed transition from atrophic telogen follicles to hypertrophic basaloid islands infiltrated by lymphocytes, resembling the pattern previously described in cutaneous lymphadenoma. Immunophenotyping showed a predominance of helper T-cells which, on ultrastructural examination, showed cerebriform nuclei. The unusual histological findings in our case may be analogous to the hyperplasia seen in sweat glands in syringotropic mycosis fungoides (syringolymphoid hyperplasia), and we propose the term basaloid folliculolymphoid hyperplasia to describe this feature. Basaloid follicular hyperplasia has been previously described as a component of follicular mucinosis but...Continue Reading
References
Apr 1, 1992·Journal of Cutaneous Pathology·J WechslerE S Zafrani
Jan 1, 1992·Dermatology : International Journal for Clinical and Investigative Dermatology·G Burg, C Schmöckel
Jul 1, 1992·The British Journal of Dermatology·S Oliwiecki, J Ashworth
Apr 1, 1991·Mayo Clinic Proceedings·D A MehreganS A Muller
Feb 1, 1991·The American Journal of Surgical Pathology·D J Santa CruzJ T Headington
Mar 1, 1989·Journal of the American Academy of Dermatology·L E GibsonM S Peters
Jan 1, 1984·The British Journal of Dermatology·F Vakilzadeh, E B Bröcker
Dec 1, 1994·Journal of Cutaneous Pathology·M M TomaszewskiW D James
Jun 1, 1994·The British Journal of Dermatology·B ZelgerB Zelger
Sep 1, 1993·Pediatric Dermatology·M de la Luz Orozco-CovarrubiasR Ruiz-Maldonado
Mar 1, 1993·The British Journal of Dermatology·R Botella, R M Mackie
Oct 1, 1957·A.M.A. Archives of Dermatology·H PINKUS
Citations
Jun 9, 2001·Clinics in Dermatology·S Kossard
Mar 28, 2002·Advances in Anatomic Pathology·Vincent Liu, Phillip H McKee
May 19, 2005·The American Journal of Dermatopathology·Steven Kossard, Paul Weller
Aug 28, 2007·The American Journal of Surgical Pathology·Pedram Gerami, Joan Guitart
Aug 8, 2008·The American Journal of Surgical Pathology·Dmitry V KazakovMichal Michal
Dec 5, 1998·The Australasian Journal of Dermatology·J R Sullivan, S Kossard
Mar 1, 1997·Journal of Cutaneous Pathology·A C GilliamK E Salhany
Sep 21, 2010·Annals of Diagnostic Pathology·Jeong Hee Cho-VegaFrancisco Vega
Mar 20, 2013·Journal of Cutaneous Pathology·Margareth Pierre-LouisMaria K Hordinsky
Sep 7, 2000·Ceskoslovenská patologie·F FakanS Námĕstek
Nov 7, 2006·Journal of Cutaneous Pathology·J Andrew CarlsonJoseph Schwartz
Dec 6, 2007·Journal of Cutaneous Pathology·Pedram Gerami, Joan Guitart
Jul 20, 1999·Dermatologic Clinics·C Jaworsky, A C Gilliam
Feb 23, 1999·The American Journal of Dermatopathology·S Kossard
Dec 12, 2001·Journal of Cutaneous Pathology·M J FlaigC A Sander
Feb 18, 2003·The British Journal of Dermatology·A GarcovichG Massi
Oct 29, 2021·Dermatology and Therapy·Eve LebasArjen F Nikkels
Jun 17, 2021·The American Journal of Dermatopathology·Steven KossardDedee Murrell