Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features.

Archives of Pathology & Laboratory Medicine
Tie-Jun LiShu-Yuan Xiao

Abstract

Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands. The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features. We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases. Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, name...Continue Reading

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Citations

Jul 6, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Ling NieXiangshan Fan
Apr 10, 2020·Archives of Pathology & Laboratory Medicine·Deepika SavantZhaohai Yang
Jul 10, 2007·Virchows Archiv : an International Journal of Pathology·Valerio MarciMauro Papotti
Aug 2, 2007·The American Journal of Surgical Pathology·Luca Di TommasoJuan Rosai
Jul 18, 2008·International Journal of Oral and Maxillofacial Surgery·G-Y YuM-J Wu
Oct 14, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y KobayashiT Shimoda
Dec 7, 2007·Cirugía española·Alvaro Díaz de LiañoHéctor Ortiz
Sep 10, 2009·The American Journal of Surgical Pathology·Andrew M BellizziEdward B Stelow

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