PMID: 2015227Apr 16, 1991Paper

Base- and sequence-dependent binding of aristololactam beta-D-glucoside to deoxyribonucleic acid

R NandiM Maiti


The dependence on base-pair composition and sequence specificity of the (aristololactam beta-D-glucoside)-DNA interaction was examined by spectrophotometric, spectrofluorometric, spectropolarimetric, thermal melting, thermodynamic, and viscometric studies. Binding of this alkaloid to various natural and synthetic DNAs was dependent upon the base composition and sequences of DNA. The binding parameters obtained from spectrophotometric analysis, according to an excluded-site model, indicated a relatively high affinity of the alkaloid binding to GC-rich DNA and alternating GC polymer. This affinity was further evidenced by the quenching of fluorescence intensity, decrease in quantum yield, and perturbations in circular dichroic spectrum. The alkaloid stabilized all DNAs against thermal denaturation. The temperature dependence of the binding constants was used to estimate the thermodynamic parameters involved in the complex formation of the alkaloid with various DNAs. The negative enthalpy and entropy change increased with increasing GC content of DNA and also compensated one another to produce a relatively small Gibbs free energy change. Viscometric studies showed that in the strong binding region the increase of contour length of...Continue Reading


Jul 30, 1990·Biochimica Et Biophysica Acta·R NandiM Maiti
Jan 1, 1990·Journal of Natural Products·J M CassadyC J Chang
Sep 1, 1989·Equine Veterinary Journal·P M McCue, W D Wilson
Dec 15, 1987·Biochemistry·J B ChairesM J Waring
Apr 1, 1987·The Biochemical Journal·S NeidleJ V Skelly
Aug 1, 1987·Journal of Biomolecular Structure & Dynamics·M Maiti, R Nandi
Jul 1, 1987·Analytical Biochemistry·M Maiti, R Nandi
Feb 1, 1985·Biochemical Pharmacology·R Nandi, M Maiti
Nov 1, 1985·Photochemistry and Photobiology·R NandiM Maiti
May 26, 1972·Biochemical and Biophysical Research Communications·J RamsteinM Leng
Dec 20, 1974·Nature·M J Waring, L P Wakelin
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Oct 1, 1968·Biopolymers·D M Crothers
Jan 1, 1981·Annual Review of Biochemistry·M J Waring
Jun 7, 1982·FEBS Letters·M MaitiK Chaudhuri
Jun 9, 1981·Biochemistry·J L Bresloff, D M Crothers

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Nov 2, 1993·Biochemical Pharmacology·G S KumarM Maiti
Nov 29, 1994·Biochemical Pharmacology·A Sen, M Maiti
Nov 8, 2003·Bioorganic & Medicinal Chemistry·Gopinatha Suresh KumarMotilal Maiti
Jun 11, 2005·Bioorganic & Medicinal Chemistry·Kakali BhadraMotilal Maiti
Aug 1, 1991·Journal of Biomolecular Structure & Dynamics·D DebnathM Maiti
Nov 20, 2002·Journal of Biomolecular Structure & Dynamics·Motilal MaitiRuma Nandi
Jul 12, 2003·Journal of Biomolecular Structure & Dynamics·Arghya RayMotilal Maiti
Jun 30, 2007·Biochimica Et Biophysica Acta·Prabal Giri, Gopinatha Suresh Kumar
May 9, 2006·International Journal of Biological Macromolecules·Prabal GiriGopinatha Suresh Kumar
Jun 13, 2015·Journal of Biomolecular Structure & Dynamics·Abhi Das, Gopinatha Suresh Kumar

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