Base docking model of the homomeric alpha7 nicotinic receptor-beta-amyloid(1-42) complex

Biochemical and Biophysical Research Communications
L Michel Espinoza-Fonseca

Abstract

A homology model of the human alpha7 nicotinic receptor was constructed based on the acetylcholine-binding protein crystal structure. Subsequently, the three-dimensional structure of the complex between the alpha7 nicotinic receptor and the 42-amino acid beta-amyloid peptide was obtained for the first time with the aid of the ESCHER program, a well-known method for protein-protein docking. The final complex showed that the most important interactions occur between the residues V12-K28 from the peptide and the loop C of the receptor. The model agrees with many experimental data, and may be used as a base model for further detailed studies in order to gain insight into the binding and dynamics of the complex at molecular level and their correlation with the memory impairments characteristic of the Alzheimer's disease.

References

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Citations

Apr 20, 2005·Current Opinion in Structural Biology·Valentina Tozzini
Sep 20, 2012·Chemical Reviews·Damien LemoineThomas Grutter
Sep 29, 2004·Biochemical and Biophysical Research Communications·L Michel Espinoza-Fonseca
Jul 1, 2005·The Journal of Biological Chemistry·Margaret H MagdesianSérgio T Ferreira
Feb 26, 2019·Frontiers in Cellular Neuroscience·Matías LasalaCecilia Bouzat
Sep 3, 2020·International Journal of Molecular Sciences·Evgeny P BarykinAlexander A Makarov
Jul 19, 2011·Biochemical Pharmacology·H Rheinallt ParriKelly T Dineley

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