Base excision repair in nucleosome substrates

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Indu JagannathanJeffrey J Hayes

Abstract

Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with nucleosome substrates, and discuss the possibility that some of the activities involved in BER are compatible with the organization of DNA within nucleosomes. In addition, we examine evidence for the role of accessory factors, such as histone modification enzymes, and the role of the histone tail domains in moderating the activities of BER factors on nucleosomal substrates.

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Citations

Dec 9, 2010·Nucleic Acids Research·Svetlana V KhoronenkovaGrigory L Dianov
Sep 21, 2011·Nucleic Acids Research·Hervé MenoniDimitar Angelov
Jun 4, 2008·Molecular and Cellular Biology·Toyotaka IshibashiJuan Ausió
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Jan 16, 2009·Biochemical Society Transactions·Shinichi KiyonariYoshizumi Ishino
Aug 21, 2015·World Journal of Gastroenterology : WJG·Juliana Carvalho Santos, Marcelo Lima Ribeiro

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