Base-Mediated Syntheses of Di- and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes

Chemistry : a European Journal
Xiao Yun ChenCarsten Bolm

Abstract

A new transition metal-free method for the preparation of substituted imidazoles from easy-to-handle amidine hydrochlorides and bromoacetylenes has been developed. The reactions proceed in air and use inexpensive K2 CO3 as base. Additions of 2,2'-bipyridine and water have beneficial effects on the product yields. Various di- and trisubstituted imidazoles have been prepared in good yields (up to 88 %).

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Jan 31, 2018·Chemical Communications : Chem Comm·Guangbin JiangHuanfeng Jiang
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hina MehmoodRuimao Hua
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