Baseline adverse electrical remodeling and the risk for ventricular arrhythmia in Cardiac Resynchronization Therapy Recipients (MADIT CRT)

Journal of Cardiovascular Electrophysiology
Yitschak BitonWojciech Zareba

Abstract

Adverse electrical remodeling (AER), represented here as the sum absolute QRST integral (SAI QRST), has previously been shown to be directly associated with the risk for ventricular arrhythmia (VA). Cardiac resynchronization therapy (CRT) is known to reduce the risk for VA through various mechanisms, including reverse remodeling, and we aimed to evaluate the association between baseline AER and the risk for VA in CRT recipients. The study population comprised 961 CRT-D implanted patients from the MADIT CRT study. The relationship between SAI QRST, VA risk, and VA risk/death was evaluated as a continuous and as a categorical variable-tertiles (T1 ≤ 0.527, T2 0.528-0.766, T3 > 0.766). In a multivariable model, AER was inversely associated with the risk of VA. Each unit increase in SAI QRST was associated with 64% (P  =  0.007) and 54% (P  =  0.003) decrease in the risk of VA and VA/death, respectively. Patients with high SAI QRST (T3) and medium SAI QRST (T2) had 52% (P < 0.001) and 32% (P  =  0.027) reduced risk for VA and 44% (P  =  0.002) and 26% (P  =  0.055) reduced risk for VA/death as compared with patients with low SAI QRST (T1), respectively. In CRT implanted patients with mild heart failure, baseline AER was inversely a...Continue Reading

References

Nov 9, 2005·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Arthur J MossWojciech Zareba
Dec 13, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jean-Philippe CoudercArthur J Moss
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Sep 14, 2010·Journal of Electrocardiology·Larisa G TereshchenkoRonald D Berger
Nov 16, 2010·The New England Journal of Medicine·Anthony S L TangUNKNOWN Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators
Sep 4, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jean-Claude DaubertJose Luis Zamorano
Apr 1, 2014·The New England Journal of Medicine·Ilan GoldenbergArthur J Moss
Dec 3, 2014·Journal of Electrocardiology·Caroline J M van DeursenLiliane Wecke
Aug 15, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Larisa G TereshchenkoUNKNOWN SMART-AV Trial Investigators
Oct 16, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Eszter M VéghFrits W Prinzen
Jan 23, 2016·Journal of the American College of Cardiology·Yitschak BitonAlon Barsheshet
Jun 7, 2016·The American Journal of Cardiology·Jonatan JacobssonLarisa G Tereshchenko
Nov 28, 2017·Cardiac Electrophysiology Clinics·Pok Tin TangNoel G Boyle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.