Jan 3, 2016

Baseline and long-term fibrinogen levels and risk of sudden cardiac death: A new prospective study and meta-analysis

Atherosclerosis
Setor KunutsorJari A Laukkanen

Abstract

Inflammatory markers such as C-reactive protein (CRP) and interleukin-6 have been linked with an increased risk of sudden cardiac death (SCD), but the relationship between fibrinogen and SCD is uncertain. We aimed to assess the association between fibrinogen and SCD. Plasma fibrinogen was measured at baseline in a prospective cohort of 1773 men aged 42-61 years free of heart failure or cardiac arrhythmias, that recorded 131 SCDs during 22 years follow-up. Correction for within-person fibrinogen variability was made using data from repeat measurements taken several years apart. Fibrinogen was strongly correlated with CRP, weakly correlated with several cardiovascular risk markers, and was log-linearly associated with SCD risk. In analyses adjusted for conventional risk factors, the hazard ratio (HR) (95% CIs) for SCD per 1 standard deviation (SD) higher baseline loge fibrinogen was 1.32 (1.11-1.57). The results remained consistent on further adjustment for alcohol consumption, resting heart rate, and circulating lipids 1.30 (1.09-1.56). The corresponding HRs were 1.80 (1.25-2.58) and 1.74 (1.20-2.52) after correction for within-person variability. HRs remained unchanged on further adjustment for CRP and accounting for incident c...Continue Reading

  • References44
  • Citations9

References

  • References44
  • Citations9

Citations

Mentioned in this Paper

Biological Markers
C1S
Research
Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Classification
C-reactive Protein Measurement
Follow-up
Fibrinogen
Fibrinogen Assay

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