Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes

Arthritis Research & Therapy
Emma C de MoelDiane van der Woude

Abstract

The autoantibody profile of seropositive rheumatoid arthritis (RA) is very diverse and consists of various isotypes and antibodies to multiple post-translational modifications. It is yet unknown whether this varying breadth of the autoantibody profile is associated with treatment outcomes. Therefore, we investigated whether the composition of the autoantibody profile in RA, as a marker of the underlying immunopathology, influences initial and long-term treatment outcomes. In serum from 399 seropositive patients with RA in the IMPROVED study, drawn at baseline and at the moment of drug tapering, we measured IgG, IgM, and IgA isotypes for anti-cyclic citrullinated peptide-2 and anti-carbamylated protein antibodies, IgM and IgA rheumatoid factor, and reactivity against four citrullinated and two acetylated peptides (anti-modified protein antibodies (AMPAs)). We investigated the effect of the breadth of the autoantibody profile on (1) change in disease activity score (DAS)44 between 0 and 4 months, (2) initial drug-free remission (DFR, drug-free DAS44 < 1.6) achieved between 1 and 2 years of follow up, and (3) long-term sustained DFR until last follow up. Patients with a broad autoantibody profile at baseline had a significantly be...Continue Reading

References

Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ShiLeendert A Trouw
Dec 18, 2013·Annals of the Rheumatic Diseases·Jing ShiLeendert A Trouw
Oct 3, 2014·The Journal of Rheumatology·Lillian BarraUNKNOWN CATCH Investigators
May 21, 2015·Annals of the Rheumatic Diseases·Michaela A StofferTanja A Stamm
Jul 15, 2015·Annals of the Rheumatic Diseases·Maria JuarezKarim Raza
Aug 16, 2017·Arthritis Research & Therapy·Myrthe A M van DelftLeendert A Trouw

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Citations

Jul 27, 2018·Annals of the Rheumatic Diseases·Emma C de MoelDiane van der Woude
Dec 18, 2019·Immunological Reviews·Mikhail VolkovDiane van der Woude
Nov 28, 2019·Mediators of Inflammation·Qinghua FangKutty Selva Nandakumar
Dec 19, 2018·Frontiers in Medicine·Serena BugattiRoberto Caporali
Nov 8, 2020·Scientific Reports·Lorena Rodriguez-MartínezAntonio Gonzalez
Dec 12, 2020·Nature Reviews. Rheumatology·Georg SchettJohn D Isaacs
Mar 3, 2021·Annals of the Rheumatic Diseases·Veerle F A M DerksenDiane van der Woude
Dec 15, 2020·Arthritis & Rheumatology·Josephine A M P AmkreutzDiane van der Woude
Sep 9, 2021·Clinical Reviews in Allergy & Immunology·Maria V SokolovaUlrike Steffen

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Methods Mentioned

BETA
ELISA

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