Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial

JAMA Cardiology
Judith S HochmanISCHEMIA Research Group

Abstract

It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (<50% for imaging stress test and <70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. Enrolled, excluded, and randomized participants' baseline characteristics. No clinical outcomes are reported. A total of 851...Continue Reading

References

Jun 1, 1987·Annals of Internal Medicine·D B MarkD B Pryor
May 1, 1985·Journal of the American College of Cardiology·R M CaliffG S Wagner
Mar 1, 1984·Journal of the American College of Cardiology·D A WeinerF Tristani
Dec 19, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rory HachamovitchDaniel S Berman
Mar 28, 2007·The New England Journal of Medicine·William E BodenUNKNOWN COURAGE Trial Research Group
Jun 9, 2009·The New England Journal of Medicine·UNKNOWN BARI 2D Study GroupBurton E Sobel
Jul 7, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Patrick W SerruysFriedrich W Mohr
Jun 18, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Siu-Sun YaoFarooq A Chaudhry
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Jun 14, 2014·JACC. Cardiovascular Imaging·Leslee J ShawUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute-Sponsored ISCHEMIA Trial Investigators
Oct 18, 2014·Journal of the American College of Cardiology·Nils P JohnsonK Lance Gould
Nov 14, 2015·JACC. Cardiovascular Imaging·Jamieson M Bourque, George A Beller
Jun 2, 2017·Journal of the American Heart Association·Nicola GaibazziAndrea Igoren Guaricci
May 21, 2018·American Heart Journal·UNKNOWN ISCHEMIA Trial Research GroupYves Rosenberg

❮ Previous
Next ❯

Citations

Nov 14, 2019·Circulation. Cardiovascular Quality and Outcomes·Jonathan D NewmanDavid J Maron
Dec 14, 2019·Circulation. Cardiovascular Interventions·Thomas J FordColin Berry
Jun 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dominik C Benz, Andreas A Giannopoulos
Apr 1, 2020·The New England Journal of Medicine·Sripal BangaloreUNKNOWN ISCHEMIA-CKD Research Group
Apr 3, 2020·Journal of Cardiovascular Translational Research·Belén Díaz-AntónLeticia Fernández-Friera
Apr 1, 2020·The New England Journal of Medicine·David J MaronUNKNOWN ISCHEMIA Research Group
May 31, 2020·Journal of Nephrology·Alexandru BurlacuUNKNOWN EUDIAL Working Group of ERA-EDTA
Apr 21, 2020·The International Journal of Cardiovascular Imaging·Suvasini LakshmananMatthew J Budoff
Nov 20, 2019·European Heart Journal Cardiovascular Imaging·Paul Knaapen
Apr 1, 2020·The New England Journal of Medicine·Elliott M Antman, Eugene Braunwald
Jan 28, 2020·The Journal of Clinical Investigation·Thorsten M LeuckerGary Gerstenblith
Jul 6, 2020·Herz·Silvia SmolkaStephan Achenbach
Apr 1, 2020·The New England Journal of Medicine·John A SpertusUNKNOWN ISCHEMIA Research Group
May 18, 2020·European Heart Journal Cardiovascular Imaging·Robert J H MillerDaniel S Berman
Aug 25, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Leonardo De LucaGian Piero Perna
Jan 19, 2021·Circulation. Cardiovascular Imaging·Raymond J Gibbons
Aug 9, 2020·JACC. Cardiovascular Imaging·Leslee ShawY Chandrashekhar
Oct 21, 2020·Journal of Cardiovascular Computed Tomography·Mouaz H Al-Mallah
Jan 25, 2020·Journal of the American College of Cardiology·Joanna Chikwe, David H Adams
Apr 3, 2020·Deutsches Ärzteblatt International·Hans R FigullaHolger Thiele
Nov 18, 2020·European Heart Journal Cardiovascular Imaging·Pepijn A van DiemenPaul Knaapen
Mar 5, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·M Bilal IqbalUNKNOWN British Columbia Cardiac Registry Investigators
Mar 30, 2021·Radiology. Cardiothoracic Imaging·Jonathon A Leipsic, Stephan Achenbach
Aug 28, 2021·Current Treatment Options in Cardiovascular Medicine·Christopher A HansonTodd C Villines
Sep 16, 2021·Circulation·Jonathan D NewmanDavid J Maron
Sep 10, 2021·Circulation·Harmony R ReynoldsJudith S Hochman
Oct 29, 2021·Circulation·Karen P Alexander, Pamela S Douglas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.