Abstract
To determine the relationship between computed tomography (CT) radiomic features and gene expression levels in head and neck squamous cell carcinoma (HNSCC). This retrospective study included 66 patients with HNSCC primary lesions (36 oropharyngeal, 6 hypopharyngeal, 10 laryngeal, 14 oral cavity). Gene expression information for 6 targetable genes (fibroblast growth factor receptor [FGFR]1, epidermal growth factor receptor [EGFR], FGFR2, FGFR3, EPHA2, PIK3CA) was obtained via Agilent microarrays from samples collected between 1997 and 2010. Pretreatment contrast-enhanced soft tissue neck CT scans were reviewed, and 142 radiomics features were derived. R was used to calculate Pearson correlation coefficients were calculated between gene expression levels and each radiomic feature. P values were adjusted using the false discovery rate (FDR) method. There were significant correlations between FGFR1 and 5 gray level cooccurrence matrix (GLCM) features with FDR-adjusted P values less than 0.05: inertia (r = 0.366, FDR-adjusted P = 0.006), absolute value (r = 0.31, FDR-adjusted P = 0.024), contrast (r = 0.366, FDR-adjusted P = 0.006), difference average (r = 0.31, FDR-adjusted P = 0.024), and difference variance (r = 0.37, FDR-adjust...Continue Reading
References
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·André Lopes CarvalhoLuiz Paulo Kowalski
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Jul 24, 2012·Radiology·C Carl Jaffe
Dec 1, 2012·European Journal of Radiology·Francesca NgVicky Goh
Apr 27, 2013·Cancer Discovery·Vivian W Y LuiJennifer R Grandis
Jul 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J WaneboA A Forastiere
Jul 25, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tanguy Y SeiwertPeter S Hammerman
Sep 27, 2014·AJNR. American Journal of Neuroradiology·M DangJ C Dort
Dec 11, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaela K KeckTanguy Y Seiwert
Aug 8, 2015·Journal of the American College of Radiology : JACR·Maciej A Mazurowski
Oct 27, 2015·AJR. American Journal of Roentgenology·Efe OzkanBarbaros S Erdal
Feb 13, 2016·The British Journal of Radiology·Harrison X BaiSharon J Diskin
Mar 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Koos KooleStefan M Willems
Jan 4, 2017·Expert Review of Precision Medicine and Drug Development·Vishwa Parekh, Michael A Jacobs
Jan 22, 2017·Oncotarget·Yi CaiGloria H Su
Apr 19, 2017·Scientific Reports·Yucheng ZhangFarzad Khalvati
Oct 14, 2017·AJNR. American Journal of Neuroradiology·M Becker
Oct 14, 2017·AJNR. American Journal of Neuroradiology·H KunoO Sakai
Nov 29, 2017·Breast Cancer Research and Treatment·Caroline LohrischKaren A Gelmon
Dec 25, 2017·Advances in Experimental Medicine and Biology·Thomas F GajewskiStefani Spranger
Jun 30, 2018·British Journal of Cancer·Ranee MehraRobert Haddad
Aug 27, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Seung Hwan MoonSe-Hoon Lee
Mar 22, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S TrebeschiH J W L Aerts
Apr 30, 2019·Quantitative Imaging in Medicine and Surgery·Tamari A MillerDaniel T Ginat
Jul 25, 2019·The New England Journal of Medicine·Yohann LoriotUNKNOWN BLC2001 Study Group