Baseline factors as predictors of clinical progression of benign prostatic hyperplasia in men treated with placebo

The Journal of Urology
E David CrawfordMTOPS RESEARCH Group

Abstract

We analyzed data from the placebo arm of the MTOPS trial to determine clinical predictors of BPH progression. A total of 3,047 patients with LUTS were randomized to either placebo, doxazosin (4 to 8 mg), finasteride (5 mg), or a combination of doxazosin and finasteride. Average length of followup was 4.5 years. The primary outcome was time to overall clinical progression of BPH, defined as either a confirmed 4-point or greater increase in AUA SS, acute urinary retention, incontinence, renal insufficiency, or recurrent urinary tract infection. We analyzed BPH progression event data from the 737 men who were randomized to placebo. The rate of overall clinical progression of BPH events in the placebo group was 4.5 per 100 person-years, for a cumulative incidence (among men who had at least 4 years of followup data) of 17%. The risk of BPH progression was significantly greater in patients on placebo with a baseline TPV of 31 ml or greater vs less than 31 ml (p <0.0001), a baseline PSA of 1.6 ng/dl or greater vs PSA less than 1.6 ng/dl (p = 0.0009), a baseline Qmax of less than 10.6 ml per second vs 10.6 ml per second or greater (p = 0.011), a baseline PVR of 39 ml or greater vs less than 39 ml (p = 0.0008) and baseline age 62 years...Continue Reading

References

Sep 1, 1984·The Journal of Urology·S J BerryL L Ewing
Aug 1, 1997·The Journal of Urology·S J JacobsenM M Lieber
May 6, 1998·Pediatric Clinics of North America·H Hennes
May 30, 2001·Urology·S A KaplanUNKNOWN Proscar Long-Term Efficacy and Safety Study Group
Jul 18, 2002·European Urology·Claus G RoehrbornUNKNOWN PLESS Study Group. Proscar Long-term Efficacy and Safety Study
Dec 19, 2003·The New England Journal of Medicine·John D McConnellUNKNOWN Medical Therapy of Prostatic Symptoms (MTOPS) Research Group

❮ Previous
Next ❯

Citations

Jul 2, 2011·Journal of General Internal Medicine·Jay H FowkeUNKNOWN Urologic Diseases of America Project
Sep 13, 2013·Current Urology Reports·Matt T RosenbergMartin Miner
Apr 15, 1981·Developmental Biology·S S WilsonW B Stallcup
Aug 30, 2003·Journal of the American College of Surgeons·Gerald H Jordan
Nov 13, 2008·International Journal of Impotence Research·C G Roehrborn
Nov 13, 2008·International Journal of Impotence Research·S Scofield, S A Kaplan
Nov 21, 2012·Prostate Cancer and Prostatic Diseases·M GacciM Maggi
Jul 20, 2012·The New England Journal of Medicine·Aruna V Sarma, John T Wei
Dec 31, 2009·International Journal of Clinical Practice·M T RosenbergD R Staskin
Jun 19, 2014·Chinese Journal of Integrative Medicine·Chun-Sheng SongQiang Zhang
Apr 16, 2014·Cutaneous and Ocular Toxicology·Zeynep AktasBerati Hasanreisoglu
Jun 26, 2007·Current Medical Research and Opinion·Sebastiano SpataforaUNKNOWN AURO.it BPH Guidelines Committee
Jan 13, 2016·Nature Reviews. Urology·Linda VignozziMario Maggi
Jul 17, 2013·Actas urologicas españolas·B MiñanaE Pedrosa
Dec 27, 2011·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A DescazeaudUNKNOWN Comité des troubles mictionnels de l’homme de l’Association française d’urologie
Jan 5, 2011·Journal of Vascular and Interventional Radiology : JVIR·João M PiscoAntonio G Oliveira
Nov 26, 2010·The Medical Clinics of North America·Claus G Roehrborn
Aug 14, 2010·Primary Care·Bob DjavanHerbert Lepor
Sep 26, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A de la Taille
May 20, 2008·The Journal of Urology·Steven A KaplanWilliam D Steers
Dec 7, 2007·The Urologic Clinics of North America·Durwood E Neal
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Alessandro SciarraFranco Di Silverio
Jul 10, 2007·European Urology·Alessandro SciarraVincenzo Gentile
Apr 10, 2007·European Urology·Stephan MadersbacherGeorg Schatzl
Jun 12, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Taiji TsukamotoMartin M Crane
Jun 15, 2007·BJU International·Mark R E HarrisMark J Speakman
Aug 20, 2008·BJU International·Christopher B AndersonKevin T McVary
Oct 31, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumimasa FukutaTaiji Tsukamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.