Baseline GABA concentration and fMRI response

NeuroImage
Manus J DonahueP Jezzard

Abstract

Coordination between glutamatergic excitatory neurons and gamma-aminobutyric acid (GABA)-ergic inhibitory interneurons is fundamental to the regulation of neuronal firing rates and is believed to have relevance to functional magnetic resonance imaging (fMRI) contrast. While much is known regarding the molecular behavior of excitatory and inhibitory processes, comparatively less is known regarding the role of such processes in explaining variations in fMRI and related hemodynamic imaging metrics. The relationship between baseline GABA levels, as measured by MR spectroscopy, and hemodynamic contrasts from four sequences in human visual cortex are investigated (n=12; field strength=3.0 T): blood oxygenation level-dependent (BOLD), cerebral blood flow (CBF)-weighted arterial spin labelling (ASL), cerebral blood volume (CBV)-weighted vascular-space-occupancy (VASO), and arterial CBV (aCBV)-weighted inflow VASO (iVASO). Results indicate that baseline GABA levels (GABA+ macromolecules normalized to creatine) inversely correlate with BOLD reactivity (R=-0.70; P=0.01) and magnitude CBV-weighted VASO reactivity (R=-0.71; P=0.01). A trend for significance was found between baseline aCBV-weighted iVASO (R=-0.50; P=0.10) and baseline GABA. ...Continue Reading

Citations

Apr 10, 2012·PloS One·Lars MichelsRuth L O'Gorman
Jan 9, 2014·Neuroscience Letters·Benjamin W KrauseLaura M Rowland
Jan 24, 2012·AJNR. American Journal of Neuroradiology·L M Levy, A J Degnan
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuzheng HuYihong Yang
Dec 4, 2015·NeuroImage·Saeedeh AmirmohseniEsther Pogatzki-Zahn
Apr 30, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark MikkelsenC John Evans
Aug 21, 2013·Neuroscience·K E WeaverI Fine
Dec 31, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin SimpsonJamie Near
Feb 10, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sanna GeversAart J Nederveen
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas Scherf, Frank Angenstein
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Petr BednaříkSilvia Mangia
Dec 15, 2015·NMR in Biomedicine·Muhammad G SalehErnesta M Meintjes
Jan 18, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jamie NearPeter Jezzard
Feb 4, 2011·NMR in Biomedicine·Matthew GeramitaStefano Marenco
Nov 3, 2011·Journal of Magnetic Resonance Imaging : JMRI·Richard A E EddenPeter B Barker
Apr 11, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E AufhausG Ende
Nov 29, 2012·Journal of Magnetic Resonance Imaging : JMRI·C John EvansRichard A E Edden
Apr 22, 2011·Journal of Magnetic Resonance Imaging : JMRI·Ruth L O'GormanErnst Martin
Dec 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·Jarunee IntrapiromkulRichard A E Edden
Dec 4, 2014·Human Brain Mapping·Michele VeldsmanAmy Brodtmann
Jan 11, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ashley D HarrisRichard A E Edden
Sep 22, 2012·Human Brain Mapping·Christine WiebkingGeorg Northoff
Mar 23, 2012·Developmental Cognitive Neuroscience·Julia J HarrisDavid Attwell
Aug 13, 2015·European Archives of Psychiatry and Clinical Neuroscience·Bin ZhangMartin Walter
May 31, 2014·NeuroImage·Jamie NearJakob Udby Blicher
Dec 19, 2012·NeuroImage·Paul G MullinsRichard A E Edden
Nov 19, 2013·NeuroImage·Emma L HallMatthew J Brookes
Jun 7, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stephanie C LicataScott E Lukas
May 26, 2015·Current Biology : CB·Claudia LunghiHolly Bridge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.