Baseline insulin sensitivity affects response to high-amylose maize resistant starch in women: a randomized, controlled trial

Nutrition & Metabolism
Barbara A GowerChristine Pelkman

Abstract

Resistant starch (RS) is a type of dietary fiber that can improve glucose metabolism, but its effects may be modulated by sex or baseline insulin sensitivity. This study was designed to examine the effect of high-amylose maize resistant starch (HAM-RS2) on insulin sensitivity (SI) in women, and to determine if SI status affects the response to RS. This was a randomized, placebo-controlled, double-blind, cross-over study. Participants were 40 healthy, non-diabetic women aged 22-67 years in the normal-weight to obese BMI range (20.6-47.4 kg/m(2)). Two doses of HAM-RS2 were tested, 15 and 30 g per day, administered in the form of cookies. Participants were randomized to the order in which they received the experimental and placebo product. Each arm was 4 weeks, with a 4-week wash-out period in between. SI was assessed at the end of each 4-week arm of product consumption by frequently-sampled, insulin-modified, intravenous glucose tolerance test and minimal modeling. Participants were categorized as being insulin resistant (IR; SI < 7.8) or insulin sensitive (IS; SI ≥ 7.8) based on Gaussian analysis. The effect of treatment arm on SI was examined by mixed-model analysis within IR and IS sub-groups, using all available data. In addi...Continue Reading

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Citations

Oct 21, 2016·Clinical & Translational Immunology·Raphael Jose Ferreira FelizardoNiels Olsen Saraiva Câmara
Feb 11, 2018·Journal of the Science of Food and Agriculture·Luis A Bello-PerezJuscelino Tovar
Sep 5, 2019·Molecular Nutrition & Food Research·Barbara WaltherGuy Vergères
Aug 26, 2020·The Journal of Nutrition·Derek C MiketinasMindy A Patterson
Sep 23, 2018·Journal of the International Society of Sports Nutrition·Sinead Mary O'ConnellGraeme Paul Young
Oct 8, 2020·European Journal of Clinical Nutrition·Barbara A GowerSuzanne Judd
Sep 23, 2020·The British Journal of Nutrition·Ke XiongAiguo Ma
Apr 14, 2020·Journal of the Academy of Nutrition and Dietetics·Ursula WhiteEric Ravussin
Aug 28, 2019·Clinical Nutrition ESPEN·María M Adeva-AndanyAna María Pedre-Piñeiro

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Nutrition Data Systems for Research (
MINMOD

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