Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab

Journal for Immunotherapy of Cancer
Mariaelena CaponePaolo Antonio Ascierto

Abstract

Previous studies have suggested that elevated neutrophil-to-lymphocyte ratio (NLR) is prognostic for worse outcomes in patients with a variety of solid cancers, including those treated with immune checkpoint inhibitors. This was a retrospective analysis of 97 consecutive patients with stage IV melanoma who were treated with nivolumab. Baseline NLR and derived (d) NLR were calculated and, along with other characteristics, correlated with progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. The best cutoff values for NLR and dNLR were derived using Cutoff Finder software based on an R routine which optimized the significance of the split between Kaplan-Meier survival curves. In univariate analysis, increasing absolute neutrophil count (ANC), NLR, dNLR and lactate dehydrogenase (LDH) (continuous variables) were all significantly associated with OS. Only NLR (hazard ratio [HR] = 2.85; 95% CI 1.60-5.08; p < 0.0001) and LDH (HR = 2.51; 95% CI 1.36-4.64; p < 0.0001) maintained a significant association with OS in multivariate analysis. Patients with baseline NLR ≥5 had significantly worse OS and PFS than patients with NLR < 5, as did patients with baseline dNLR ≥3 versus < 3. Optimal cut-o...Continue Reading

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Citations

Oct 17, 2019·Frontiers in Immunology·Pacôme LecotMarie-Cécile Michallet
Jun 1, 2020·Journal for Immunotherapy of Cancer·John P LynesEdjah K Nduom
Jul 23, 2020·Nature Reviews. Cancer·Sebastien JaillonAlberto Mantovani
Mar 13, 2020·Journal of Translational Medicine·Mariaelena CaponePaolo A Ascierto
Apr 16, 2020·Cancers·Marit J van ElsasSjoerd H van der Burg
Apr 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Elif Hindié
Mar 31, 2019·Journal for Immunotherapy of Cancer·Paolo A AsciertoJulia Grigorieva
Nov 19, 2019·BioMed Research International·Media N IsmaelRoniel Cabrera
Aug 15, 2020·Frontiers in Immunology·Elisa PeranzoniIlaria Marigo
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Jun 21, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A Hernando-CalvoE Muñoz-Couselo

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Software Mentioned

SPSS
Cutoff Finder
R

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