Baseline psychopathology and relationship to longitudinal functional outcome in attenuated and early first episode psychosis

Schizophrenia Research
Cynthia Z BurtonWilliam R McFarlane

Abstract

As efforts intensify to intervene early among those at risk for psychosis, examination of the relationship between presenting psychopathology and long-term functional outcome may guide treatment decision-making and offer a means to prevent or reduce chronic disability. Data were collected through the Early Detection and Intervention for the Prevention of Psychosis Program (EDIPPP), a multisite national trial testing the efficacy of an early intervention for youth at risk of developing psychosis. Participants were followed prospectively and completed comprehensive evaluations at 6, 12, and 24 months, including the Structured Interview for Prodromal Syndromes (SIPS) and the Global Social and Role Functioning Scales. The present analyses included 327 participants and examined the relationships between baseline symptoms and longitudinal global social and role functioning using a linear mixed modeling approach. Higher baseline negative symptoms and deteriorated thought process predicted worse social and role functioning in the follow-up period. The effect of negative symptoms on social functioning, however, was moderated by positive symptoms, and the relationship between positive symptoms and social functioning changed over time. Ba...Continue Reading

Citations

Jul 8, 2020·Journal of Child and Adolescent Psychopharmacology·Jerome H TaylorMichael H Bloch
Oct 14, 2020·Early Intervention in Psychiatry·Sophie M AllanSheri Oduola
Jul 16, 2021·European Archives of Psychiatry and Clinical Neuroscience·Oemer Faruk OeztuerkNikolaos Koutsouleris
Aug 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eloi Giné-ServénJavier Labad

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