Baseline Renal Function and Albumin are Powerful Predictors for Allogeneic Transplantation-Related Mortality

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Roni ShouvalJan J Cornelissen

Abstract

Biomarkers measured in blood chemistry before allogeneic hematopoietic stem cell transplantation (HSCT) may reflect patients' physiological status. We hypothesized that selected markers are predictive for nonrelapse mortality (NRM) following transplantation and could contribute to risk assessment. We investigated the value of pre-HSCT albumin, estimated glomerular filtration rate (eGFR), and alkaline phosphatase (AlkP) in predicting NRM. We retrospectively analyzed clinical and laboratory data from 1217 patients receiving a first HSCT in 2 European centers between 2003 and 2015. Transplantation indications and conditioning regimens were diverse. Patients had a median age of 55 years and hematopoietic cell transplantation comorbidity index (HCT-CI) scores of 0 (24%), 1 to 2 (39%), and ≥3 (37%). Cutoffs of eGFR <60 mL/min, albumin <3.5 g/dL, and AlkP >180 IU/L corresponded with 8.8%, 8.3%, and 6.5% of the patients, respectively. eGFR and albumin were associated with increased risk and higher cumulative incidence of day-100, 1-year, and 2-year NRM, both as continuous or categorized variables. A similar pattern was observed for AlkP, except for day-100 NRM. In multivariable analyses, eGFR and albumin were consistently among the top...Continue Reading

Citations

Jan 4, 2019·Bone Marrow Transplantation·Karen SweissPritesh R Patel
Dec 14, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Naonori HaradaHirohisa Nakamae
Mar 30, 2021·Transplantation and Cellular Therapy·Nosha FarhadfarMarcelo Pasquini
Jan 15, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eita MiyashitaArinobu Tojo

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