Baseline Renal Function Predicts Hyponatremia in Liver Cirrhosis Patients Treated with Terlipressin for Variceal Bleeding

Gastroenterology Research and Practice
Sung Eun KimChoongKee Park

Abstract

Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. This retrospective, case-control study investigated 88 cirrhotic patients who developed hyponatremia and 176 controls that did not develop hyponatremia and were matched in terms of age and gender during the same period following terlipressin administration. The overall change in serum sodium concentration and the mean lowest serum sodium concentration were 3.44 ± 9.55 and 132.44 ± 8.78 mEq/L during treatment, respectively. Multivariate analysis revealed that baseline serum sodium was an independent positive predictor, and the presence of baseline serum creatinine, HBV, DM, creatinine, and shock on admission was independent negative predictors of hyponatremia (P < 0.05). The presence of HBV, DM, the baseline serum sodium, shock on admission, and especially baseline creatinine may be predictive of the development of hyponatremia after terlipressin treatment. Therefore, physicians con...Continue Reading

References

Aug 1, 1989·Radiology·A Di LelioL Beretta
May 1, 1980·The Journal of Endocrinology·M L ForslingB Donovan
Jan 22, 2000·Seminars in Liver Disease·G D'AmicoJ Bosch
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A EscorsellJ Bosch
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gennaro D'AmicoUNKNOWN Cooperative Study Group
Nov 20, 2003·Critical Care : the Official Journal of the Critical Care Forum·Cheryl L HolmesJohn T Granton
Feb 28, 2004·American Journal of Nephrology·Rajendra Bhimma, Hoosen Mohamed Coovadia
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Apr 6, 2006·World Journal of Gastroenterology : WJG·Cun-Liang DengMing-Yong Wang
Apr 25, 2007·Scandinavian Journal of Gastroenterology·Elaine Dunwoodie, Sarah Jowett
Sep 20, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Aug 30, 2008·American Journal of Physiology. Renal Physiology·Aleksander KragSøren Møller
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Mar 23, 2010·Scandinavian Journal of Gastroenterology·Jong Jin HyunHo Sang Ryu
Oct 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elsa SolàPere Ginès
Jun 1, 2012·Kidney International Supplements
Oct 21, 2015·Kidney Research and Clinical Practice·Hye Min ChoiHyoung Kyu Kim

❮ Previous
Next ❯

Citations

Aug 20, 2019·Journal of Clinical Pharmacy and Therapeutics·Qingbo MengHaohao Wang

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Praveen SharmaShiv Kumar Sarin
Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
A Albillos Martínez
© 2022 Meta ULC. All rights reserved