Baseline sebum IL-1α is higher than expected in afro-textured hair: a risk factor for hair loss?

Journal of Cosmetic Dermatology
Renée A BeachN P Khumalo

Abstract

To investigate changes in sebum cytokines in response to hair cosmetics. Design and setting  A prospective study at a University hospital. We used a novel method for scalp surface sebum collection (Sebutape(®)) on three visits, sequentially a week apart, to investigate changes in six cytokines in 36 healthy women before and after shampoo and compared various chemical treatments (ammonium thioglycolate, "lye" sodium hydroxide and "no-lye" guanidine hydroxide relaxers) performed by a professional hairdresser. Significant levels detected were IL-1 alpha (IL-1α) and IL-1 receptor antagonist (IL-1ra), which were higher in untreated scalp vs. forehead: P < 0.001. Baseline levels of scalp sebum IL-1α were 18 times higher than IL-1ra. The levels of IL-1α decreased uniformly after shampoo (visit 1) and various chemical treatments (both crown and vertex all P < 0.001 - visit 2) but increased on follow-up at visit 3. Decreases in IL-1ra mimicked IL-1α at the vertex [after shampoo (P = 0.018) and visit 3 (P = 0.014)], but not on the crown, a finding which may suggest site-specific scalp predisposition to inflammation. The ratio of IL-1ra/IL-1α increased in all groups after all chemical treatments and on follow-up (all P < 0.001) but was su...Continue Reading

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Citations

Apr 1, 2014·Dermatologic Clinics·Temitayo A OgunleyeElise A Olsen
Sep 3, 2013·Journal of Cosmetic Dermatology·Nattaya Lourith, Mayuree Kanlayavattanakul
Aug 20, 2015·Veterinary Dermatology·Jacqueline R GimmlerDawn M Boothe
Aug 14, 2020·Stem Cell Reviews and Reports·Richard P Halley-StottNonhlanhla P Khumalo
May 15, 2012·The British Journal of Dermatology·N P Khumalo, F Gumedze

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