Baseline serum levels of osteopontin predict clinical response to treatment with nivolumab in patients with non-small cell lung cancer

Clinical & Experimental Metastasis
Federico CarboneFabrizio Montecucco

Abstract

Treatment with nivolumab improves survival and response rate in non-small cell lung cancer (NSCLC). Nevertheless, due to its high financial cost, identifying predictors of response to treatment has become an urgent need. Here, we focused on serum osteopontin (OPN), a pleiotropic protein overexpressed in lung cancer and involved in the immune response. A cohort of NSCLC patients (n = 72) treated with nivolumab was enrolled. Blood samples were collected at the time of first five nivolumab administrations. OPN and high-sensitivity C-reactive protein (hs-CRP) were assayed at each time point. The primary endpoint was to assess the predictive value of baseline serum levels of OPN towards overall survival (OS). Secondary endpoints included the potential association between OPN, hs-CRP and response to nivolumab. OPN and hs-CRP correlate with each other, with neutrophil count and biochemical markers of metastatic disease. At baseline, serum OPN increased with increasing Eastern Cooperative Oncology Group scale of Performance Status (ECOG PS). When Eastern Cooperative Oncology Group scale of Performance Status) (RECIST) criteria were considered, high baseline OPN levels were associated with a worse response to nivolumab. Cox hazard regre...Continue Reading

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Citations

Dec 22, 2019·Cancers·Erika RijavecFrancesco Grossi
Feb 13, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A BonaventuraF Montecucco
Oct 16, 2020·Biomarkers in Medicine·Stefano MinistriniFabrizio Montecucco
Jul 25, 2021·Cancers·Julien AncelValérian Dormoy
Aug 15, 2021·European Journal of Clinical Investigation·Federico CarboneFabrizio Montecucco

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS Statistics
MedCalc

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