PMID: 15352492Sep 9, 2004Paper

Baseline toxicity of a chlorobenzene mixture and total body residues measured and estimated with solid-phase microextraction

Environmental Toxicology and Chemistry
Heather A LeslieMichiel H S Kraak

Abstract

Body residues of compounds with a narcotic mode of action that exceed critical levels result in baseline toxicity in organisms. Previous studies have shown that internal concentrations in organisms also can be estimated by way of passive sampling. In this experiment, solid-phase microextraction (SPME) fibers were used as a tool to estimate the body residues, which were then compared to measured levels. Past application of SPME fibers in the assessment of toxicity risk of samples has focused on separate exposure of fibers and organisms, often necessitated by the amount of agitation needed in order to achieve steady state in the fibers within a convenient time period. Uptake kinetic studies have shown that in SPME fibers with thin coatings, equilibrium concentrations can be reached without agitation within the time frame of a toxicity test. In contrast to toxicity experiments to date, the SPME fibers in the current study were exposed concomitantly to the test water with the organisms, ensuring an exposure under the exact same conditions. Fibers and two aquatic invertebrate species were exposed to a mixture of four chlorobenzenes with a narcotic mode of action. The total body residue of these compounds in the organisms was determi...Continue Reading

Citations

Jun 21, 2011·Bulletin of Environmental Contamination and Toxicology·Christopher M HurdzanDavid M Sovic
Apr 25, 2006·Environmental Toxicology and Chemistry·Lance J SchulerMichael J Lydy
Jul 7, 2012·Environmental Toxicology and Chemistry·Yuping DingMichael J Lydy
Sep 8, 2010·Environmental Toxicology and Chemistry·Sharon E HookThomas F Parkerton
Dec 25, 2010·Integrated Environmental Assessment and Management·Scott DyerBeate I Escher
Jul 13, 2012·Environmental Toxicology and Chemistry·Yuping DingMichael J Lydy
May 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Krzysztof GoryńskiBarbara Bojko
Jun 19, 2007·Environmental Toxicology and Chemistry·Lance J SchulerMichael J Lydy
Feb 10, 2012·Environmental Science & Technology·Amanda D HarwoodMichael J Lydy
May 21, 2020·Environmental Science & Technology·Azin EftekhariGlenn C Morrison

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