Baselines representing blood glucose clearance improve in vitro prediction of the glycaemic impact of customarily consumed food quantities

The British Journal of Nutrition
John A MonroBernard J Venn

Abstract

Glycaemic responses to foods reflect the balance between glucose loading into, and its clearance from, the blood. Current in vitro methods for glycaemic analysis do not take into account the key role of glucose disposal. The present study aimed to develop a food intake-sensitive method for measuring the glycaemic impact of food quantities usually consumed, as the difference between release of glucose equivalents (GGE) from food during in vitro digestion and a corresponding estimate of clearance of them from the blood. Five foods - white bread, fruit bread, muesli bar, mashed potato and chickpeas - were consumed on three occasions by twenty volunteers to provide blood glucose response (BGR) curves. GGE release during in vitro digestion of the foods was also plotted. Glucose disposal rates estimated from downward slopes of the BGR curves allowed GGE dose-dependent cumulative glucose disposal to be calculated. By subtracting cumulative glucose disposal from cumulative in vitro GGE release, accuracy in predicting the in vivo glycaemic effect from in vitro GGE values was greatly improved. GGE(in vivo) = 0.99GGE(in vitro)+0.75 (R(2) 0.88). Furthermore, the difference between the curves of cumulative GGE release and disposal closely m...Continue Reading

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Citations

Aug 9, 2012·Plant Foods for Human Nutrition·Kerry L Bentley-HewittAnton Pernthaner
Jan 16, 2015·Critical Reviews in Food Science and Nutrition·Bhupinder KaurJeyakumar Henry
Sep 10, 2015·Journal of Food Science·Bhupinder KaurC Jeya K Henry
Jun 6, 2013·Journal of the Science of Food and Agriculture·Hussam A A RazzaqLidia Motoi
Jun 18, 2011·Journal of the Science of Food and Agriculture·Hussam A A RazzaqLidia Motoi
Mar 10, 2015·Critical Reviews in Food Science and Nutrition·Sushil DhitalMichael J Gidley
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·K J ShingfieldY Chilliard
Mar 9, 2017·Journal of Food Science·Alessandra MartiMaria Cristina Casiraghi
Jan 29, 2013·International Journal of Food Sciences and Nutrition·Yean Yean SoongC Jeya K Henry
Jun 9, 2020·NPJ Digital Medicine·Lennaert van VeenYan Fossat
Aug 15, 2012·International Journal of Food Sciences and Nutrition·Viren Ranawana, C Jeya K Henry
Feb 19, 2021·NPJ Digital Medicine·Lennaert van VeenYan Fossat
Jul 6, 2021·The British Journal of Nutrition·Akila SrvJohn Alexander Monro

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