Basement membrane and stroke

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Yao Yao

Abstract

Located at the interface of the circulation system and the CNS, the basement membrane (BM) is well positioned to regulate blood-brain barrier (BBB) integrity. Given the important roles of BBB in the development and progression of various neurological disorders, the BM has been hypothesized to contribute to the pathogenesis of these diseases. After stroke, a cerebrovascular disease caused by rupture (hemorrhagic) or occlusion (ischemic) of cerebral blood vessels, the BM undergoes constant remodeling to modulate disease progression. Although an association between BM dissolution and stroke is observed, how each individual BM component changes after stroke and how these components contribute to stroke pathogenesis are mostly unclear. In this review, I first briefly introduce the composition of the BM in the brain. Next, the functions of the BM and its major components in BBB maintenance under homeostatic conditions are summarized. Furthermore, the roles of the BM and its major components in the pathogenesis of hemorrhagic and ischemic stroke are discussed. Last, unsolved questions and potential future directions are described. This review aims to provide a comprehensive reference for future studies, stimulate the formation of new ...Continue Reading

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Citations

Jun 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Max I BogoradPeter C Searson
Jul 12, 2019·Translational Stroke Research·Jyoti GautamYao Yao
Mar 4, 2020·Stroke; a Journal of Cerebral Circulation·Minkyung Kang, Yao Yao
Nov 22, 2019·CNS Neuroscience & Therapeutics·Tuo YangFeng Zhang
Apr 8, 2020·Journal of Neuroinflammation·Jyoti GautamYao Yao
Aug 28, 2020·Frontiers in Physiology·Moises Freitas-AndradeBaptiste Lacoste
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Anuska V AndjelkovicRichard F Keep
Jan 30, 2019·Translational Stroke Research·Jyoti GautamYao Yao
May 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dong Young KimYoung-Guen Kwon
Mar 7, 2020·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Feb 20, 2019·Acta Neuropathologica Communications·Abhijit NirwaneYao Yao
Feb 18, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Markus GindorfClaus U Pietrzik
Nov 27, 2020·CNS Neuroscience & Therapeutics·Zhangyang WangXin Wang
Jun 22, 2021·Neurochemistry International·Mengqi ZhangKe-Jie Yin
Apr 30, 2020·Current Neuropharmacology·Guofang Shen, Qingyi Ma
Nov 14, 2021·Glia·Minkyung Kang, Yao Yao

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
electron microscopy
transgenic

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