PMID: 640305Mar 13, 1978Paper

Basement membrane formation in transfilter tooth culture and its relation to odontoblast differentiation

Differentiation; Research in Biological Diversity
I ThesleffL Saxén

Abstract

The mesenchymal cells of the developing tooth differentiate into odontoblasts as a result of an epithelio-mesenchymal interaction. Odontoblast differentiation was studied in vitro by cultivating dental mesenchyme and epithelium with interposed filters. Separation of the two components by enzyme treatment resulted in removal of the basement membrane. When the epithelium was grown alone, or transfilter from killed lens capsule, the basement membrane was not restored. Transfilter cultivation with dental mesenchyme resulted in basement membrane formation, but only if the filter pores allowed penetration of cytoplasmic processes. Hence, a close association between the epithelial and the mesenchymal cells seems to be a prerequisite for the restoration of the basement membrane. Differentiation of odontoblasts took place only in explants in which a basement membrane was formed. Differentiation did not occur when contact of the mesenchymal cells with the basement membrane was prevented by small pore size filters. Further experiments demonstrating an intact basement membrane suggested that membrane contacts between the epithelial and the mesenchymal cells are not needed for odontoblast differentiation. Hence, we suggest that differentiat...Continue Reading

References

Jul 1, 1977·Developmental Biology·I ThesleffL Saxén
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Citations

Mar 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H ZhouJ E Davies
Jan 1, 1981·Cell and Tissue Research·J M MeyerJ V Ruch
Dec 1, 1983·In Vitro·I ThesleffE Ruoslahti
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Jun 1, 1981·European Journal of Biochemistry·H Lesot
Aug 5, 2005·Archives of Histology and Cytology·Masaki J HondaMinoru Ueda
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Jan 1, 1983·Differentiation; Research in Biological Diversity·J ArechagaJ V Ruch

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