Basement membrane remodelling regulates mouse embryogenesis

Nature
Christos KyprianouMagdalena Zernicka-Goetz

Abstract

Tissue sculpting during development has been attributed mainly to cellular events through processes such as convergent extension or apical constriction1,2. However, recent work has revealed roles for basement membrane remodelling in global tissue morphogenesis3-5. Upon implantation, the epiblast and extraembryonic ectoderm of the mouse embryo become enveloped by a basement membrane. Signalling between the basement membrane and these tissues is critical for cell polarization and the ensuing morphogenesis6,7. However, the mechanical role of the basement membrane in post-implantation embryogenesis remains unknown. Here we demonstrate the importance of spatiotemporally regulated basement membrane remodelling during early embryonic development. Specifically, we show that Nodal signalling directs the generation and dynamic distribution of perforations in the basement membrane by regulating the expression of matrix metalloproteinases. This basement membrane remodelling facilitates embryo growth before gastrulation. The establishment of the anterior-posterior axis8,9 further regulates basement membrane remodelling by localizing Nodal signalling-and therefore the activity of matrix metalloproteinases and basement membrane perforations-t...Continue Reading

References

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Aug 9, 2019·Nature Communications·Neophytos ChristodoulouMagdalena Zernicka-Goetz

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Citations

Dec 16, 2020·Developmental Cell·Katharine Goodwin, Celeste M Nelson
Feb 7, 2021·Development·Lillian B SpatzJason C Mills
Dec 31, 2020·Developmental Cell·Gianluca AmadeiMagdalena Zernicka-Goetz
Sep 23, 2020·Advanced Drug Delivery Reviews·Jennifer Patten, Karin Wang
May 21, 2021·Current Opinion in Cell Biology·David R Sherwood
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Christine LangDagmar Iber
Aug 22, 2021·Trends in Cell Biology·Jinglei ZhaiHongmei Wang
Nov 2, 2021·Cell Cycle·Evangéline Despin-Guitard, Isabelle Migeotte
Dec 16, 2021·Development·Jesse V VeenvlietVikas Trivedi
Dec 16, 2021·Physical Biology·Andrew D DoyleKenneth M Yamada

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Datasets Mentioned

BETA
AB769

Methods Mentioned

BETA
single-cell sequencing
immunoprecipitation
genotyping
FCS
Protein Assay
PCR
Assay

Software Mentioned

Seurat
CellEvent
Fiji
R
Imaris
ImageJ
Integrative Genomics Viewer
Oriana
Leica LASX

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