Basic and clinical aspects of autoimmune disorders in peripheral nerves

Acta Neurologica Scandinavica. Supplementum
Hugh J Willison

Abstract

This presentation discusses the immunobiology of the Guillain Barré syndromes (GBS), the world's leading cause of acute autoimmune neuromuscular paralysis. By gaining an understanding of the clinical and pathophysiological pathways operating in GBS, we can hope to develop novel immunotherapies that will improve clinical outcome. Here we focus on GBS mediated by anti-ganglioside antibodies and highlight the correlations between anti-ganglioside antibody patterns and clinical phenotypes, the development of models of GBS, and the application of novel therapies based on inhibition of complement activation.

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Citations

Sep 7, 2006·The Journal of Clinical Investigation·Richard M Ransohoff
Jun 4, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tamara Vyshkina, Bernadette Kalman

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