Basic and Clinical Pharmaco-Therapeutics of SGLT2 Inhibitors: A Contemporary Update

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Sanjay KalraJignesh K Ved

Abstract

Clinical relevance of sodium/glucose cotransporter 2 (SGLT2) inhibitors has been rapidly evolving across several therapy areas, apart from type 2 diabetes mellitus. While some of these developments are based on recognized scientific explanations, unexpected study findings have also shaped much of our present understanding. As the role of these agents evolves in various facets of cardiology, nephrology, hepatology and endocrinology, their optimum clinical value propositions should be realized in line with the principles of personalized medicine. An updated pharmaco-ergonomic qualification tool, based on the present evidence with these agents, would be a step in this direction. This review describes the present evidence on diverse pharmacological and therapeutic aspects for various SGLT2 inhibitors, as an attempt to provide useful guidance for optimum application in clinical practice.

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Citations

May 28, 2020·International Journal of Environmental Research and Public Health·Maria MirabelliAntonio Brunetti
Jan 2, 2021·Current Problems in Cardiology·Rahul GuptaAaqib H Malik
Nov 6, 2020·International Journal of Nephrology and Renovascular Disease·George Vasquez-Rios, Girish N Nadkarni
Nov 14, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·David M WilliamsMarc Evans

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Methods Mentioned

BETA
amputations

Software Mentioned

DIVE
CANVAS
REG
CREDENCE
EMPA
DAPA HF

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