Basic concepts of artificial neural networks (ANN) modeling in the application to pharmaceutical development

Pharmaceutical Development and Technology
J BourquinH Leuenberger

Abstract

Artificial neural networks (ANN) methodology is a new modeling method that has not been broadly applied to pharmaceutical sciences up to now. The aim of this paper is to give a detailed description of the associating networks as well as a description of less well-known networks (i.e., feature-extracting and nonadaptive networks) and their scope of application in pharmaceutical sciences. The descriptions include the historical origin and the basic concepts behind the computing. ANN are based on the attempt to model the neural networks of the brain. Learning algorithms for associating ANN use mathematical procedures usually derived from the gradient descent method whereas feature-extracting ANN map multidimensional input data sets onto two-dimensional spaces. Nonadaptive ANN map data sets and are able to reconstruct their patterns when presented with corrupted or noisy samples. Associating networks can typically be applied in the pharmaceutical field as an alternative to traditional response surface methodology, feature-extracting networks as alternative to principal component analysis, and nonadaptive networks for image recognition. Based on these abilities, the potential application fields of the ANN methodology in the pharmace...Continue Reading

References

Aug 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·P Veng-Pedersen, N B Modi
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G ReibneggerH Wachter
Oct 1, 1991·Pharmaceutical Research·A S HussainR D Johnson
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Jan 1, 1982·Journal of Mathematical Biology·E Oja
Feb 1, 1993·Pharmaceutical Research·R J Erb
Apr 30, 1993·Journal of Medicinal Chemistry·D J Livingstone, D T Manallack
Jan 1, 1996·Journal of Pharmaceutical Sciences·B P Smith, M E Brier
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Jun 1, 1949·Journal of Comparative and Physiological Psychology·D O HEBB

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Citations

Dec 1, 2005·Drug Development and Industrial Pharmacy·Névine Rizkalla, Patrice Hildgen
Jul 2, 2009·Journal of Pharmaceutical Sciences·T SoványK Pintye-Hódi
Sep 1, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Krisanin ChansanrojGabriele Betz
Sep 9, 2006·International Journal of Pharmaceutics·A GhaffariM Rafiee-Tehrani
Jan 5, 2002·Pharmaceutical Development and Technology·R KuppuswamyL L Augsburger
Aug 10, 2006·Pharmaceutical Development and Technology·Yingxu PengAtul J Shukla
May 17, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A Philip PlumbMartin Brown
Nov 11, 2010·Pharmaceutical Development and Technology·Celil Tan, İsmail Tuncer Degim
Sep 10, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·E A ColbournP York

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