Basic epidemiological parameter values from data of real-world in mega-cities: the characteristics of COVID-19 in Beijing, China

BMC Infectious Diseases
Xiaoli WangC Raina MacIntyre

Abstract

With the spread of SARS-CoV-2 worldwide, understanding the basic epidemiological parameter values of COVID-19 from real-world data in mega-cities is essential for disease prevention and control. To investigate the epidemiological parameters in SARS-CoV-2 infected cases in Beijing, we studied all confirmed cases and close contacts in Beijing from Jan 1st to Apr 3rd 2020. The epidemiological and virological characteristics of SARS-CoV-2 were analyzed. A total of 602 cases were positive for SARS-CoV-2, including 585 confirmed patients and 17 asymptomatic infections. The imported cases were mainly from Wuhan initially and then from abroad. Among 585 confirmed case-patients, the median age was 39 years old. The mean incubation period was 6.3 days. The secondary attack rate among households was higher than social contacts (15.6 vs 4.6%). The secondary attack rate of healthcare workers (HCWs) was higher than non-HCWs' (7.3 vs 4.2%). The basic reproduction number was 2.0, and the average serial interval was 7.6 days. No significant genetic variant was identified. The transmissibility of SARS-CoV-2 was relatively high, especially among households and from HCWs, which draws specific public health attention. So far, no evidence of widespr...Continue Reading

References

May 27, 2003·Science·Marc LipsitchMegan Murray
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Xinghuo PangDaniel R Feikin
Mar 20, 2004·Emerging Infectious Diseases·Denise Li-Meng GohChorh Chuan Tan
Oct 29, 2009·Emerging Infectious Diseases·Peng YangQuanyi Wang
Oct 3, 2017·Briefings in Bioinformatics·Kazutaka KatohKazunori D Yamada
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 7, 2020·Journal of Medical Virology·Xingguang LiAntoine Chaillon
Feb 7, 2020·Journal of Medical Virology·Carmine Ceraolo, Federico M Giorgi
Feb 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kelvin Kai-Wang ToKwok-Yung Yuen
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses

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Citations

Dec 15, 2020·JAMA Network Open·Zachary J MadewellNatalie E Dean
Apr 15, 2021·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Alejandro López-EscobarPaula Sol Ventura
Feb 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hayley A ThompsonNeil M Ferguson
May 12, 2021·BMJ Global Health·Fatuma Hassan GuleidEdwine Barasa
May 27, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheikh Taslim AliBenjamin J Cowling

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Methods Mentioned

BETA
Illumina sequencing

Software Mentioned

GraphPad Prism
SPSS

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