Apr 1, 1976

Basic ethers of cyclohexylphenols with beta-blocking activity: synthesis and pharmacological study of exaprolol

M CarissimiF Ravenna


The paper describes the preparation and study of the pharmacological properties of a series of derivatives with the general formula. (see article) where R is a cyclohexyl or cyclohexenyl radical and R1 is a hydrogen, methyl or cyclohexyl. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the beta-adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.

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Mentioned in this Paper

Myocardial Contraction
Ethers for general anesthesia
Diastolic Blood Pressure
Anti-Arrhythmia Agents
Smooth Muscle
Local Anesthetic [EPC]

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