PMID: 8067246Jan 1, 1994Paper

Basic experimental studies of ostial patency and local metabolic environment of the maxillary sinus

Acta Oto-laryngologica. Supplementum
R AustB Drettner

Abstract

Experimental studies of human maxillary sinus gas exchange show that there is a balance between inflow of air through the maxillary ostium and local consumption as long as the functional size of the ostium is at least 5 mm2. Maxillary sinus mucosal blood flow is 30-40 ml/100 g tissue per minute, as measured in plethysmographic studies. This blood flow can bind and transport only half of the absorbed oxygen, the rest is consumed. Experimental histo- and biochemical studies of sinusitis show anaerobic mucosal metabolism with shortage of energy supply due to inadequate oxygen supply. There is no decrease in oxidative enzyme capacity of the mucosal epithelium. Analysis of organic acids in purulent secretion indicates that the high lactate and CO2 concentration found is mainly the result of leucocyte glycolysis with local lactic acidosis. Both ostial occlusion and the initiation of bacterial growth in serous sinusitis may be secondary to an initial inflammatory response, resulting in local tissue pathology and swelling of the ostiomeatal complex, as well as creating the appropriate redox potential for further bacterial growth in the secretions.

References

Jul 1, 1977·Acta Oto-laryngologica·C Carenfelt, C Lundberg
Jan 1, 1978·Acta Oto-laryngologica·C Carenfelt, C Lundberg
Sep 1, 1978·Arthritis and Rheumatism·I BrookS M Finegold
Nov 1, 1975·Acta Oto-laryngologica·R Aust, B Drettner
Nov 1, 1974·Acta Oto-laryngologica·R Aust, B Drettner
Nov 1, 1967·Acta Oto-laryngologica·B Drettner, C E Lindholm

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Citations

Oct 30, 2008·The Journal of Laryngology and Otology·J Keir
Feb 1, 1996·The Laryngoscope·S K MikulaW Lawson
Nov 23, 2013·AJR. American Journal of Roentgenology·Nir HirshorenAviv Hirschenbein
Nov 27, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ahmet KutluhanAkif Sinan Bilgen
Oct 28, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jon O Lundberg
Sep 19, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·N M TimmengaR van Weissenbruch
May 10, 2008·Journal of Chemotherapy·S EspositoUNKNOWN Italian Society of Microbiology
Sep 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anju T PetersRaymond G Slavin
Jan 7, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kasper AanaesPeter Østrup Jensen
May 1, 1996·Acta Oto-laryngologica·Y G MinS Yoon
Jan 1, 2015·Vestnik otorinolaringologii·V N KrasnozhenYu A Garskova
May 15, 2020·HNO·H L SieronJ Lindemann
Feb 8, 2022·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Panagiotis D PyriochosIordanis Konstantinidis

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