Basic Fibroblast Growth Factor Ameliorates Endothelial Dysfunction in Radiation-Induced Bladder Injury

BioMed Research International
Shiwei ZhangHongqian Guo

Abstract

This study was designed to explore the effect of basic fibroblast growth factor (bFGF) on radiation-induced endothelial dysfunction and histological changes in the urinary bladder. bFGF was administrated to human umbilical vein cells (HUVEC) or urinary bladder immediately after radiation. Reduced expression of thrombomodulin (TM) was indicated in the HUVEC and urinary bladder after treatment with radiation. Decreased apoptosis was observed in HUVEC treated with bFGF. Administration of bFGF increased the expression of TM in HUVEC medium, as well as in the urinary bladder at the early and delayed phases of radiation-induced bladder injury (RIBI). At the early phase, injection of bFGF increased the thickness of urothelium and reduced inflammation within the urinary bladder. At the delayed phase, bFGF was effective in reducing fibrosis within the urinary bladder. Our results indicate that endothelial dysfunction is a prominent feature of RIBI. Administration of bFGF can ameliorate radiation-induced endothelial dysfunction in urinary bladder and preserve bladder histology at early and delayed phases of RIBI.

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Citations

Jan 6, 2016·International Journal of Molecular Sciences·Libing YeHongyu Zhang
Mar 14, 2020·International Journal of Molecular Sciences·Hyosun JangSehwan Shim
Oct 9, 2020·Lasers in Surgery and Medicine·Vesna KaricHeidi Abrahamse

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Methods Mentioned

BETA
ELISA
electrophoresis
flow cytometry
X-Ray

Software Mentioned

Prism
Pro Plus
GraphPad
Image
Cell Quest

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