Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Kenji FujisawaMasaru Nagayama

Abstract

The therapies for refractory ulcers on the oral mucosa are symptomatic and very unsatisfactory. We hypothesized that application of growth factors might be able to achieve successful remission of the lesion. We evaluated the effects of systemic administration and topical application of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on impaired wound healing of ulcers in the rabbit gingiva. Almost uniform round ulcers could be created on the gingiva of the rabbits by chemical injury with acetic acid. When the submandibular glands were removed or i.v. injection of cisplatin (CDDP) and peplomycin sulfate was performed before ulcer formation, healing of the ulcers took longer than in untreated rabbits. To ascertain whether or not human EGF and bFGF affect rabbit cells, we first examined the effects of EGF and bFGF on the proliferation of the cells derived from rabbit gingiva. We then applied EGF or bFGF in these impaired healing models. EGF and bFGF promoted proliferation of the fibroblasts, and EGF also promoted proliferation of the keratinocytes isolated from gingival tissue of rabbits in vitro. Systemic injections of EGF and bFGF in rabbits, which had their submandibular glands removed, and topical appli...Continue Reading

References

Apr 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L BodnerI Hammel
Jul 1, 1990·The Journal of Experimental Medicine·R Tsuboi, D B Rifkin
Nov 1, 1985·Journal of the American Academy of Dermatology·R A Clark
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G F PierceT F Deuel
Sep 1, 1993·The Journal of Experimental Medicine·L Staiano-CoicoM R Madden
Aug 1, 1993·The British Journal of Surgery·E UhlK Messmer
Jan 1, 1993·Archives of Oral Biology·L BodnerI Hammel
Sep 1, 1997·Plastic and Reconstructive Surgery·K BreuingE Eriksson
Jan 1, 1997·Advances in Second Messenger and Phosphoprotein Research·L M GravesE G Krebs
Mar 26, 1998·Biochemical and Biophysical Research Communications·A ShuklaB S Srivastava
Jul 26, 2000·Acta Oto-laryngologica. Supplementum·H IshizakiI Pyykkö
Sep 16, 2000·Journal of Diabetes and Its Complications·G E OxfordM G Humphreys-Beher
Feb 15, 2002·Advances in Dental Research·H KagamiM Ueda

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Citations

Sep 10, 2013·Pathology, Research and Practice·Seda M Sarı KılıçaslanEmine G Güleç Peker
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Susumu Okabe, Kikuko Amagase
Jan 6, 2011·Journal of Oral Science·Mayra T VasquesLuciana Corrêa
Jul 5, 2008·Lasers in Medical Science·Carla Andreotti DamanteMárcia Martins Marques
Apr 14, 2015·Periodontology 2000·Matthias ChiquetDimitris Kletsas
Apr 26, 2006·Expert Opinion on Emerging Drugs·Joel B Epstein, Gary D Klasser
Dec 12, 2012·Journal of Photochemistry and Photobiology. B, Biology·Mayra Torres VasquesLuciana Corrêa
May 10, 2011·International Journal of Oral and Maxillofacial Surgery·S Y Karavana HizarcioğluJ B Epstein
Nov 9, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Charles NguyenMark Wong
Oct 19, 2010·Journal of Photochemistry and Photobiology. B, Biology·Guorui JinSeeram Ramakrishna
May 25, 2007·Burns : Journal of the International Society for Burn Injuries·Abdo JurjusRania A Tohme
Jan 9, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M N TabriziF Gorouhi
Dec 2, 2011·International Wound Journal·Zeynep Kalay, Sule Coskun Cevher
Aug 19, 2008·Archives of Oral Biology·Maria das Graças Vilela-GoulartMônica Fernandes Gomes
Dec 3, 2005·Biomaterials·Fotios M Andreopoulos, Indushekhar Persaud
Feb 11, 2015·International Journal of Oral and Maxillofacial Surgery·G de M G LimaM F Gomes
Feb 24, 2015·Dental Materials : Official Publication of the Academy of Dental Materials·Sophia P PilipchukWilliam V Giannobile
Oct 27, 2004·Journal of Dental Research·X H ZouG W Yip
Nov 11, 2014·Journal of Tissue Engineering·Carolina Al ChavesAna L Machado
Sep 27, 2005·Journal of Dental Research·H E van BeurdenA M Kuijpers-Jagtman
Jun 20, 2014·Journal of Dental Research·C T VietB L Schmidt
Aug 7, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno A L A MarizJacks Jorge
Jan 10, 2020·Biomaterials Science·Zheng LuoXian Jun Loh
Jan 24, 2006·The Journal of Dermatological Treatment·Tohru TanigawaShigeru Inafuku
Apr 25, 2018·Toxicological Research·Mi Hyun Kang, Bae-Hwan Kim
Apr 3, 2019·International Journal of Molecular Sciences·Agnieszka StempniewiczZygmunt Warzecha
Sep 29, 2018·Journal of Periodontal Research·Maria B AsparuhovaAnton Sculean
Sep 6, 2020·Oral Diseases·Koya NakamuraNarisato Kanamura
Oct 20, 2020·Journal of Food Science and Technology·Rita KhounganianFaiyaz Shakeel
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yuan LiuHui Cheng
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Jake G EdmansSebastian G Spain

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