Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps

Plastic and Reconstructive Surgery
Michael S WongBruce Klitzman

Abstract

Partial transverse rectus abdominis myocutaneous (TRAM) flap loss in breast reconstruction can be a devastating complication for both patient and surgeon. Surgical delay of the TRAM flap has been shown to improve flap viability and has been advocated in "high-risk" patients seeking autogenous breast reconstruction. Despite extensive clinical evidence of the effectiveness of surgical delay of TRAM flaps, the mechanisms by which the delay phenomenon occurs remain poorly understood. To examine whether angiogenic growth factors such as basic fibroblast growth factor (bFGF) may play a role in the delay phenomenon, the authors studied the expression of bFGF in rat TRAM flaps subjected to surgical delay. Thirty-five female Sprague-Dawley rats were randomly assigned to one of four TRAM flap groups: no delay (n = 6), 7-day delay (n = 12), 14-day delay (n = 10), or 21-day delay (n = 7). Surgical delay consisted of incising skin around the perimeter of the planned 2.5 x 5.0-cm TRAM flap followed by ablation of both superior epigastric arteries and the left inferior epigastric artery, thus preserving the right inferior epigastric artery (the nondominant blood supply to the rectus abdominis muscle of the rat). TRAM flaps were then elevated ...Continue Reading

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Citations

May 3, 2011·Plastic and Reconstructive Surgery·Matthias Artur ReichenbergerHolger Engel
Aug 30, 2013·Plastic and Reconstructive Surgery·Hede YanWeiyang Gao
Jan 29, 2013·Biomaterials·Tolga Taha SönmezMersedeh Tohidnezhad
Jan 2, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Y HarderM D Menger
Mar 25, 2016·Journal of Plastic Surgery and Hand Surgery·Murat Gorkem AtamanHuseyin Borman
Sep 18, 2014·Acta Cirúrgica Brasileira·Audrien Furlan de LuccaLydia Masako Ferreira
Oct 20, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xiucun LiXu Gong
Apr 19, 2007·Plastic and Reconstructive Surgery·Shadi GhaliGeoffrey C Gurtner
Jul 30, 2014·Craniomaxillofacial Trauma & Reconstruction·Kristy HamiltonLarry H Hollier
Apr 3, 2020·Journal of Plastic Surgery and Hand Surgery·Shanshan XiMaolin Tang

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