PMID: 8964535Apr 1, 1996Paper

Basic fibroblast growth factor in human tear fluid: detection of another growth factor

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
G B van Setten

Abstract

Topical application of various growth factors have shown promising experimental data in speeding up corneal wound healing. Similar effects have been reported for another group of proteins, fibroblast growth factors (FGFs). One of them, basic FGF (bFGF), stimulates the proliferation of cells of mesodermal as well as of neuroectodermal origin and is highly angiogenic. The aim of the present study was to investigate the presence of bFGF in human tear fluid. After establishing an advanced enzyme-linked immunosorbent assay technique, tear fluid was collected from 15 healthy individuals before and after stimulation of reflex tearing. In none of the tear fluid samples collected prior to induction of reflex tearing could FGF be detected. Of the 15 samples collected during reflex tearing, six (40%) contained measurable amounts of bFGF. The amount of bFGF appeared to decrease with increasing tear fluid flow, suggesting a dilution effect. This study gives strong evidence that bFGF, as previously shown for epidermal growth factor and transforming growth factor-alpha, may occur in human tear fluid of healthy individuals after induction of reflex tearing and, in very low concentrations, under normal conditions. Whether bFGF can to be conside...Continue Reading

References

Nov 1, 1991·International Ophthalmology·G B van SettenA Tarkkanen
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jan 1, 1989·Annual Review of Biochemistry·W H Burgess, T Maciag
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G B van SettenJ Perheentupa
Oct 1, 1987·Current Eye Research·D Fredj-ReygrobelletP Lapalus
Jan 1, 1981·Differentiation; Research in Biological Diversity·D BarritaultY Courtois
Sep 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G van Setten, G Schultz

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Citations

Jan 20, 2004·Experimental Eye Research·Darlene A Dartt
Feb 14, 2013·The FEBS Journal·Amanda WeyersRobert J Linhardt
Oct 28, 2015·Journal of Ophthalmology·Maria Rosaria De PascaleClaudio Napoli
Jul 10, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lakshmi Mitreyi GorugantulaYi-Shing Lisa Cheng
Aug 2, 2002·The Laryngoscope·Anders WestermarkGysbert van Setten
Sep 1, 2007·Proteomics. Clinical Applications·Kaili Wu, Yanli Zhang
Nov 11, 2009·Current Eye Research·Aidin SafvatiMark Willcox

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