PMID: 9448312Mar 14, 1998Paper

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

Proceedings of the National Academy of Sciences of the United States of America
Eric C Holland, Harold E Varmus

Abstract

Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors.

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Citations

Jul 14, 2000·The Journal of Gene Medicine·M H ZahlerR G Pestell
Feb 9, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jasmine LauWilliam A Weiss
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