Basic fibroblast growth factor is a morphogenic modulator in kidney vessel development

Kidney International
S KlothWill W Minuth

Abstract

During kidney organogenesis the development of renal vessels must be synchronized with the maturation of nephrons and the collecting duct system. Several reports showed that hormones and mitogenic peptides as basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) are involved in this regulatory process. It is a known fact that bFGF receptors are expressed by differentiating tubular epithelium and mesenchyme, but little information is available about the function of bFGF in kidney organogenesis. The role of bFGF during kidney development was investigated using an organotypic culture system and immunohistological techniques. Renal cortex explants were prepared from the kidneys of neonatal rabbits with a microsurgical method, retaining the natural tissue composition. The explants were cultured serum free under continuous medium perfusion. Our results indicate a new and unexpected role of bFGF during the differentiation process. When bFGF alone was applied, vessels could no longer be detected. The inhibitory influence of bFGF could be overcome by addition of VEGF or hormones such as retinoic acid and aldosterone/vitamin D3. The combination of these factors with bFGF resulted in the expression of small ve...Continue Reading

References

Dec 1, 1992·Experimental Cell Research·H T JärveläinenT N Wight
Dec 1, 1992·Differentiation; Research in Biological Diversity·S KlothW W Minuth
Jan 1, 1991·Annual Review of Physiology·M Klagsbrun, P A D'Amore
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Nov 23, 1995·The New England Journal of Medicine·K J RothmanA Milunsky
Jan 1, 1995·International Review of Cytology·M A MosesY Shing
Jan 1, 1995·Annual Review of Biochemistry·A L Means, L J Gudas
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S KlothW W Minuth
Jan 1, 1993·Growth Factors·P A D'Amore, S R Smith
Sep 1, 1993·Archives of Biochemistry and Biophysics·B S Kasinath
May 1, 1996·Kidney International·J VilarC Merlet-Bénichou
Jan 1, 1997·Cell and Tissue Research·S KlothW W Minuth
Nov 1, 1948·The American Journal of Anatomy·J G WILSON, J WARKANY

❮ Previous
Next ❯

Citations

Oct 13, 2005·Virchows Archiv : an International Journal of Pathology·Karsten GravdalLars A Akslen
May 15, 2007·Cell and Tissue Research·Ana Luisa PinaSabine Kloth
Oct 26, 1999·Trends in Neurosciences·V C Asensio, I L Campbell
Oct 18, 2000·Critical Reviews in Oncology/hematology·O Oudar
Nov 24, 1999·Kidney International. Supplement·C RoncoR Bellomo
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·C Merlet-BénichouT Gilbert
Feb 2, 2013·Clinical and Translational Medicine·Will W Minuth, Lucia Denk
Jan 8, 2000·Microvascular Research·S Kloth, C Suter-Crazzolara
Jan 26, 2010·Biomaterials·Will W MinuthAnne Glashauser
Aug 29, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Matthias FestagBruno Viertel
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Peter V HauserNorimoto Yanagawa
Dec 8, 2004·The American Journal of Pathology·Jolanta E PiteraHai Tao Yuan
Jan 15, 2010·The Journal of Nutrition·Parul Christian, Christine P Stewart
Apr 7, 2006·American Journal of Physiology. Renal Physiology·Zhuangwu LiPatricio E Ray
Feb 28, 2003·American Journal of Physiology. Cell Physiology·Tetsu Akimoto, Marc R Hammerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.