PMID: 7824196Sep 12, 1994

Basic fibroblast growth factor-like immunoreactivity in the rat basilar artery with reference to co-localization with NADPH-diaphorase in the trigeminal ganglion

Neuroscience Letters
O KadotaM Sakanaka

Abstract

The location of basic fibroblast growth factor (bFGF)-like immunoreactivity and nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase (neuronal nitric oxide synthase) activity in the rat basilar artery and in the trigeminal, sphenopalatine and superior cervical ganglia was investigated. bFGF immunoreactivity was seen mainly in adventitial nerve fibers of the rat basilar artery, but not in the endothelium. Electron microscopy of the tunica media showed a number of immunoreactive nerve endings in the vicinity of local smooth muscle cells. Among the cranial ganglia that innervate the basilar artery, only the trigeminal ganglion had bFGF-immunoreactivity neurons. Nerve cells and fibers with NADPH-diaphorase activity were detected in the basilar artery and in the sphenopalatine and trigeminal ganglia, and the co-localization of bFGF and NADPH-diaphorase was noted only in the trigeminal ganglion. Furthermore, Fluro-gold tracing in combination with bFGF immunohistochemistry demonstrated that bFGF-containing nerve fibers in the wall of the basilar artery arise from the trigeminal ganglion. These findings provide a morphological basis for the nitric oxide-mediated dilatation of cerebral arteries by bFGF.

References

Citations

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T M DawsonS H Snyder
Nov 22, 1991·Science·P CuevasG Giménez-Gallego
Sep 9, 1985·FEBS Letters·B PettmannG Labourdette
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NozakiS H Snyder
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S RosenblattM A Moskowitz
Mar 5, 1993·Neuroscience Letters·N SuzukiT Shimizu

Related Concepts

Entire Trigeminal Ganglion
Establishment and Maintenance of Localization
Media Layer
Immunohistochemistry
Immunoreactivity
NOS1 protein, human
FGF2 gene
Neurons
Myocytes, Smooth Muscle
Stilbamidines

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