Basic fibroblast growth factor potentiates myelin repair following induction of experimental demyelination in adult mouse optic chiasm and nerves.

Journal of Molecular Neuroscience : MN
Samaneh DehghanHossein Baharvand

Abstract

Induction of demyelination in the central nervous system induce the oligodendrocyte progenitors to proliferate, migrate, and differentiate for restoring new myelin sheathes around demyelinated axons. Factors which increase the response of endogenous progenitor cells could be used to improve remyelination. In the current study, the effect of bFGF on lysolecithin-induced demyelination and remyelination processes in mouse optic chiasm and nerves was investigated. Lysolecithin was injected into the optic chiasm of Balb/C mice. Two groups of animals received doses of bFGF (1 or 5 ng/kg i.p.) just before and every 3 days after lysolecithin injection. Delay and amplitude of visual evoked potential (VEP) waves were recorded as indices of axonal demyelination at 7th, 13th, and 28th days post-lesion. Myelin basic protein (MBP) and Olig2 gene expressions were studied as indices of myelination and oligodendrocyte precursors' recruitment into the lesion. Lysolecithin elongated delay of P1 wave and declined the amplitude of P1-N1 wave. Lysolecithin decreased MBP and increased Olig2 expression in different days post-lesion. Lysolecithin-induced changes in VEPs were partially ameliorated by endogenous repair. bFGF reduced the increased delay, ...Continue Reading

References

Feb 12, 1998·Journal of Neuroscience Research·R J FranklinW F Blakemore
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C ZhangI D Duncan
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W I McDonald, M A Ron
Feb 13, 2001·Trends in Neurosciences·J M LevineJ W Fawcett
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Nov 8, 2001·European Archives of Psychiatry and Clinical Neuroscience·H G KuhnE Fuchs
Jul 26, 2002·Molecular and Cellular Neurosciences·François LachapelleAnne Baron-Van Evercooren
Sep 5, 2002·Nature Reviews. Neuroscience·Robin J M Franklin
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nathalie Picard-RieraAnne Baron-Van Evercooren
Jan 18, 2003·Progress in Neurobiology·Martin Stangel, Hans-Peter Hartung
Jan 18, 2003·Journal of Neurobiology·Emma E FrostRegina C Armstrong
Apr 15, 2004·Molecular and Cellular Neurosciences·M A HackM Götz
Apr 28, 2004·The American Journal of Pathology·Jeffrey L MasonGlenn K Matsushima
Jan 11, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Eric P Guazzo
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine A G MarshallJames E Goldman
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cynthia Husted
Mar 18, 2008·Epilepsy Research·Takashi IshikawaChiaki Kamei
May 14, 2008·Brain : a Journal of Neurology·Monique Dubois-DalcqCatherine Lubetzki
Jul 28, 2011·Investigative Ophthalmology & Visual Science·Yuyi YouStuart L Graham

❮ Previous
Next ❯

Citations

Mar 27, 2016·Experimental Neurology·Natalie A Wheeler, Babette Fuss
Mar 27, 2016·Experimental Neurology·Yangyang Huang, Cheryl F Dreyfus
Apr 3, 2015·Cellular and Molecular Neurobiology·Xuebin QuRuiqin Yao
Jun 28, 2014·Frontiers in Neuroscience·Bilal El WalyPascale Durbec
Mar 16, 2018·International Journal of Preventive Medicine·Cobra PayghaniBahman Rashidi
Feb 23, 2017·Cellular and Molecular Neurobiology·Mahsa MotavafMohammad Javan
Oct 17, 2019·Frontiers in Molecular Neuroscience·Charbel S BaakliniJason R Plemel
Apr 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghavendra UpadhyaAshok K Shetty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.