Basic fibroblast growth factor transcriptional autoregulation requires EGR-1

Oncogene
D WangA S Baldwin

Abstract

Basic fibroblast growth factor (bFGF) is an important growth factor for neuroectoderm- and mesoderm-derived cells. In addition bFGF is an important angiogenic factor and appears to contribute to tumorigenesis. This is exemplified by the fact that bFGF is expressed in a large majority of human gliomas and that bFGF expression is critical for the growth and tumorigenesis of these cells. It has been shown previously that bFGF can induce its own expression through an increase in bFGF mRNA. In this report, we show that bFGF leads to its own synthesis through an autoregulated transcriptional response that requires the transcription factor Egr-1 (also known as Krox24, Zif268 and NGFI-A). Egr-1 binds to two DNA elements in the bFGF promoter and positively regulates transcription. Mutation of these sites blocks the ability of bFGF to transcriptionally regulate the bFGF promoter. These data indicate a mechanism to explain how bFGF functions to autoregulate its expression and demonstrate that Egr-1 is as an essential transcription factor in this process.

Citations

Jan 12, 2000·The Journal of Pathology·T J DorkinH Y Leung
Dec 27, 2011·Angiogenesis·Kathleen C BrownPiyali Dasgupta
Oct 28, 1998·Journal of Physiology, Paris·R M NitschH von der Kammer
Mar 1, 2012·The Journal of Biological Chemistry·Shuang-Xia ZhangXiong-Zhi Wu
Oct 17, 1998·The EMBO Journal·J SvarenJ Milbrandt
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuichi AsanoKentaro Shimokado
Oct 12, 2010·Toxicology Letters·Jeeyoun JungGeum-Sook Hwang
Feb 6, 2004·Journal of Neurochemistry·Jun HaradaChristian Waeber
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chai-Fei Li, Millie Hughes-Fulford
Mar 18, 1999·The American Journal of Pathology·E S Silverman, T Collins
Oct 14, 2000·Neurobiology of Learning and Memory·D F Clayton
Apr 3, 1999·The Journal of Biological Chemistry·T UebaF H Gage
Nov 26, 1999·Journal of Cellular Biochemistry·M S LeeC A Glackin
Oct 31, 2006·Oncogene·T D Gilmore, M Herscovitch
Nov 11, 1999·Oncogene·F Mercurio, A M Manning
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Jun 13, 2000·Oncogene·N N Danial, P Rothman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.