Basic infertility including polycystic ovary syndrome

The Medical Clinics of North America
Maryse BrassardJean-Patrice Baillargeon

Abstract

Infertility in women has many possible causes and must be approached systematically. The most common cause of medically treatable infertility is the polycystic ovary syndrome (PCOS). This syndrome is common in young women and is the cause of anovulatory infertility in 70% of cases. It is therefore an important condition to screen and manage in primary care medical settings. In the past 10 years, insulin sensitization with weight loss or metformin has been shown to be a safe and effective treatment for PCOS infertility that eliminates the risk of multiple pregnancy and may reduce the risk of early pregnancy loss as compared with ovulation-inductor drugs. The authors believe metformin should be considered as first-line therapy because it has the advantage to allow for normal single ovulation, for reduced early pregnancy loss, and, most importantly, lifestyle modifications and weight loss before pregnancy. Losing weight not only improves fertility but also reduces adverse pregnancy outcomes associated with obesity.

References

Sep 1, 1979·Metabolism: Clinical and Experimental·L Crapo
Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·T P CiaraldiS S Yen
Dec 1, 1992·The Journal of Clinical Endocrinology and Metabolism·D I SprattJ Orav
Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R PasqualiL Barbara
Jun 1, 1989·American Journal of Public Health·D A SnowdonR L Phillips
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J DevesaJ Cabezas-Cerrato
Sep 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M G Hull
Oct 22, 1988·BMJ : British Medical Journal·M SagleS Franks
Jan 22, 1987·The New England Journal of Medicine·R M MulaikalJ A Rock
Mar 1, 1985·The Journal of Clinical Endocrinology and Metabolism·P D WoolfM Kelly
Dec 14, 1985·British Medical Journal·M G HullK M Desai
Jul 1, 1966·The Anatomical Record·R P Singh, D H Carr
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R J ChangS A Kaplan
Apr 23, 1981·The New England Journal of Medicine·F R KaufmanR Koch
Jan 1, 1994·Gynecologic and Obstetric Investigation·R L Barbieri
Feb 1, 1996·Fertility and Sterility·G S ConwayH S Jacobs
Mar 16, 1996·Lancet·Y T van der SchouwJ D Banga
Dec 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A D GenazzaniA R Genazzani
Jul 1, 1997·Human Reproduction Update·E KoustaS Franks
Feb 17, 1998·Obstetrics and Gynecology·J N AnastiL M Nelson
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·H W Baker
Feb 6, 1999·Journal of Clinical Psychopharmacology·D L KleinbergM Brecher
Nov 24, 1999·The Journal of Clinical Endocrinology and Metabolism·E Diamanti-KandarakisM I Bartzis
Jan 5, 2000·Clinical Endocrinology·K F MichelmoreM P Vessey

❮ Previous
Next ❯

Citations

Feb 26, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shin-hyo LeeYasuhiro Kon
Oct 22, 2010·Endocrine·Karine Brochu-GaudreauMarie-France Palin
Jan 20, 2012·Human Reproduction·Tracey BushnikJohn Collins
Jan 19, 2012·The Nurse Practitioner·Susan Kelly-Weeder
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shan LiAiping Qin
Aug 26, 2009·Women's Health·Angelica Lindén Hirschberg
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Aleksandra Rutkowska, Dominik Rachoń
Feb 6, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hamed E EllakwaMohamed A Elsayed
May 21, 2013·Journal of the Chinese Medical Association : JCMA·Talieh KazerooniYasaman Kazerooni
Mar 4, 2014·Endocrinology and Metabolism Clinics of North America·Anindita NandiLeonid Poretsky
Nov 26, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·David UnuaneKris Poppe
Feb 2, 2010·Fertility and Sterility·Amanda A DeeksHelena J Teede
Nov 2, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S S LimL J Moran
Jan 22, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Neja MudrovcicKarolina Kublickiene
Apr 7, 2012·Genetics and Molecular Biology·Rubem R AmadorMaria de Fátima M Almeida Santos
Aug 8, 2014·Reproductive Sciences·Irfana LiaqatHugh S Taylor
Nov 1, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Peipei Jin, Yongyong Xie
Sep 21, 2017·Current Psychiatry Reports·Laura G Cooney, Anuja Dokras
Jan 30, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Wan YangYing Wang
Aug 14, 2018·Clinical Endocrinology·Emily W GilbertLisa J Moran
Jul 14, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Hongxia JiaZhaoshun Jiang
Jun 11, 2020·Therapeutic Advances in Reproductive Health·Yvonne V Louwers, Joop S E Laven
Jul 5, 2018·International Journal of Endocrinology·Alexandre ConnollyJean-Patrice Baillargeon
Nov 21, 2018·Reproductive Biology and Endocrinology : RB&E·Wan YangJie Jiao
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Fernanda Bertuccez CordeiroEdson Guimarães Lo Turco
Jan 14, 2021·Biotechnology and Applied Biochemistry·Young-Jin SimMi-Young Lee
Jan 15, 2010·Current Opinion in Obstetrics & Gynecology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

Lancet
Robert J NormanTheresa E Hickey
Fertility and Sterility
Ricardo AzzizTask Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
General Hospital Psychiatry
Peter P Roy-ByrneMurray B Stein
© 2022 Meta ULC. All rights reserved