Basic local alignment search tool

Journal of Molecular Biology
S F AltschulD J Lipman

Abstract

A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent mathematical results on the stochastic properties of MSP scores allow an analysis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DNA and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DNA sequences. In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity.

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Dec 21, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Eduard MorenoJordi Garcia-Mas
Jun 11, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhi Wei WangTing Wang
Jun 6, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Debbie L Laudencia-Chingcuanco, William H Vensel
Jul 18, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Adam HeesackerSteven J Knapp
Nov 14, 2008·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Leah K McHaleRichard W Michelmore
Jan 9, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·M Venegas-CalerónEnrique Martínez-Force
Jan 10, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Nora L V LapitanChristopher Lawrence
Apr 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Weibo XieQifa Zhang
Aug 12, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·P RamuC T Hash
Sep 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·André BelóAntoni Rafalski
Oct 1, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Anja HanemannMarion S Röder
Oct 14, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yanli LuYunbi Xu
Oct 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Wellington MucheroPhilip A Roberts
Dec 2, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Luis F MaasSusan McCouch
Jan 21, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Juliane MittaschCarsten Milkowski
Apr 10, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Cornelia LangeHeinz Himmelbauer
Apr 27, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Susan McCallumJulie Graham
Jun 2, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Yuan-Ying PengYou-Liang Zheng
Jun 30, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·E S Mace, D R Jordan
Mar 23, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Stefano CostanzoSteven A Brooks
Oct 1, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Fahimeh ShahinniaNils Stein
Nov 15, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Michel ClaverieJean-Marc Lacape
Mar 9, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·J M BushakraS E Gardiner
Mar 29, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Rosy RamanHarsh Raman
May 23, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhi LiuGuangsheng Yang
Sep 14, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·María Laura RamosCarlos A Sala
Mar 6, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·E S MaceD R Jordan
May 25, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Matthew P Kinkade, Majid R Foolad
Jul 9, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Paula Rodrigues OblessucLuciana Lasry Benchimol-Reis
Sep 18, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Johanna Acevedo-GarciaRalph Panstruga
Feb 3, 2005·Archives of Microbiology·Monika ThielM Schlömann
Sep 24, 2005·Archives of Microbiology·Alexis DumoulinBrigitte Berger-Bächi