Oct 5, 1990

Basic local alignment search tool

Journal of Molecular Biology
S F AltschulD J Lipman

Abstract

A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent mathematical results on the stochastic properties of MSP scores allow an analysis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DNA and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DNA sequences. In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity.

  • References9
  • Citations31061

References

Mentioned in this Paper

Basic Local Alignment Search Tool
Computer Programs and Programming
Homologous Sequences, Nucleic Acid
Protein Domain
Protein Sequence Databases
DNA Sequence

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