Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

Ageing Research Reviews
Ekaterina N ProshkinaA A Moskalev

Abstract

Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.

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Citations

Aug 5, 2016·Communicative & Integrative Biology·Hanaa HaririW Mike Henne
Jun 9, 2016·Experimental Gerontology·Karyn L Hamilton, Benjamin F Miller
Jul 28, 2016·Ageing Research Reviews·Hamidreza Pazoki-ToroudiSeyed Mohammad Nabavi
Jan 23, 2017·International Journal for Parasitology. Drugs and Drug Resistance·Neil H BagnallAndrew C Kotze
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Aug 24, 2018·International Journal of Molecular Sciences·Kyung-Jin Min, Marc Tatar
Jun 5, 2020·Ageing Research Reviews·Ekaterina ProshkinaAlexey Moskalev
Jun 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongmei YouJun Li
Apr 6, 2018·Journal of Agricultural and Food Chemistry·Stefanie StaatsGerald Rimbach
Sep 3, 2021·Npj Aging and Mechanisms of Disease·Li-Chun ChoChih-Fei Kao

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