Abstract
Oxidised low-density lipoprotein (LDL) contributes to atherogenesis by a number of mechanisms, and antioxidants may act as anti-atherogens. LDL oxidation is inhibited by LDL-associated antioxidants, particularly alpha-tocopherol (vitamin E), and water-soluble antioxidants present in LDL's biologic milieu, especially ascorbate (vitamin C). In addition to protecting LDL against oxidation, antioxidants may act at the level of the vascular cell by limiting cellular production of reactive oxygen species, and, thus, cell-mediated LDL oxidation. Cellular antioxidants can also protect against vascular cell dysfunction that would otherwise promote atherogenesis, such as increased adhesion molecule expression and monocyte recruitment, impaired production or release of nitric oxide, or both, and the proliferation of smooth muscle cells. Some of these processes are regulated by nuclear factor-kappa B or related transcription factors, which are redox-sensitive and inhibited by antioxidants. Furthermore, cellular antioxidants can limit cytotoxic effects of oxidised LDL and other oxidant insults, inhibiting vascular cell necrosis and lesion progression. Finally, some antioxidants, in particular alpha-tocopherol, may affect atherogenesis by in...Continue Reading
Citations
Jan 5, 2002·Comprehensive Therapy·D P Pandya
Mar 16, 2002·Comprehensive Therapy·Dipak P Pandya
Jun 17, 2000·European Journal of Pharmacology·C GöçmenF Baysal
Oct 25, 2000·Molecular Aspects of Medicine·J F Keaney
Jul 24, 2003·Journal of the American College of Cardiology·Stavroula K OsganianWalter C Willett
Sep 18, 1999·Free Radical Biology & Medicine·C K ChowA C Chan
Mar 4, 2000·Free Radical Biology & Medicine·M M Valkonen, T Kuusi
Aug 31, 1999·The Proceedings of the Nutrition Society·P A Morrissey, P J Sheehy
Apr 8, 2006·Clinical Biochemistry·Zehra SerdarAkýn Serdar
May 13, 1999·The Journal of Biological Chemistry·M RosenblatM Aviram
Feb 2, 1999·Circulation·D L Tribble
Feb 10, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·Y D Fragoso, A J Brown
May 2, 2002·Journal of Internal Medicine·K Asplund
Dec 21, 2002·Asia Pacific Journal of Clinical Nutrition·Khalid Yusoff
Feb 13, 2001·The Journal of Nutrition·A AzziJ Zingg