Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006

Transfusion
Timothy EstepR M Winslow

Abstract

In March 2006, a workshop sponsored by the National Heart, Lung, and Blood Institute was convened to identify the role of basic science research in clarifying issues that are impeding progress in the development of hemoglobin-based oxygen carrying (HBOC) solutions. These discussions resulted in a consensus that, although HBOCs have shown clinical promise, various side effects have inhibited further development and regulatory approval, with cardiovascular events being of particular concern. As a consequence, workshop participants focused on formulating research recommendations to better understand and mitigate these side effects. In addition, several important corollary issues were identified, including better understanding of the impact of HBOC infusion on human physiology; the need for rapid, noninvasive methods for the measurement of tissue oxygenation in human patients to better inform transfusion decisions; further investigation of routes and consequences of hemoglobin metabolism; optimization of clinical protocols for HBOC use; and assessment of the impact of HBOC formulation excipients. Also discussed was the possibility and desirability of developing new HBOCs with improved characteristics, such as prolonged functional i...Continue Reading

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Citations

Dec 4, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·John P Harrington, Hanna Wollocko
May 8, 2010·Chemical Communications : Chem Comm·Ronald KlugerAdelle A Vandersteen
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Jan 31, 2009·Artificial Organs·Jan SimoniJohn F Moeller
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Apr 16, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·C Robert Valeri, Gina Ragno
Apr 4, 2009·Critical Care Clinics·A Gerson Greenburg
Sep 24, 2008·Biochimica Et Biophysica Acta·Andrea Mozzarelli
Oct 6, 2010·Archives of Biochemistry and Biophysics·Serena FaggianoAndrea Mozzarelli
Aug 17, 2016·Obstetrical & Gynecological Survey·Burak ZeybekMostafa A Borahay
Dec 19, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Wentao ZhouChengmin Yang
Jan 1, 2011·Journal of Functional Biomaterials·John P Harrington, Hanna Wollocko
Mar 28, 2008·Transfusion·Christopher Stowell
Feb 1, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Wentao ZhouChengmin Yang
Mar 23, 2017·Artificial Organs·Kyle D WebsterKenneth W Olsen
Oct 30, 2008·Biochemistry·Dongxin Hu, Ronald Kluger

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